Evidence map›Paper›PMID 41542573›Full record

ArticlebioRxiv : the preprint server for biology2026

Lipid-mediated reinforcement of FGF/MAPK signaling enables robust otic placode specification.

Stephanie R Peralta, Natalia Maiorana, Michael L Piacentino

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stephanie R PeraltaDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0009-0007-4092-6456
Natalia MaioranaDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Michael L PiacentinoDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0003-1773-031X

Funding

Characterizing the cranial neural crest response to BMP signaling through gastrulation and neurulationR00DE029240 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI PIACENTINO, MICHAEL LOUIS · 2023 to 2025
$873k
NIDCR NIH HHS R00 DE029240
6 · The paper itself

Abstract

The formation of cranial placodes requires groups of ectodermal cells to interpret inductive signals in a robust and organized manner, yet how signaling responses are coordinated across a developing field remains incompletely understood. During otic placode specification, fibroblast growth factor (FGF) signaling must overcome intrinsic noise and rising inhibitory feedback to drive collective transcriptional responses, suggesting the existence of reinforcing regulatory events beyond ligand-receptor interactions and gene regulatory networks alone. Here we identify the secreted lipid-binding protein Apolipoprotein D (APOD) as an essential mediator of otic placode specification that links lipid-dependent regulation to FGF/MAPK signaling during early development. We find that

Indexed as

Apolipoprotein D (APOD)Fibroblast growth factor (FGF)Mitogen activated protein kinase (MAPK)otic placodeSpecification

Identifiers

PMID41542573
PMCPMC12803122

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.