Evidence map›Paper›PMID 41542572›Full record

ArticlebioRxiv : the preprint server for biology2026

Consumption of processed foods impairs memory function through dietary advanced glycation end-products.

Anna M R Hayes, Molly E Klug, Madhav Sharma, Alicia E Kao, Shan Sun, Edwin D J Lopez Gonzalez, Houming Zhu, Joshua C Dent, Richard J Clark, David R Sell and 19 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Anna M R HayesDepartment of Biological Sciences, Human and Evolutionary Biology Section, University of Southern California, Los Angeles, CA, USA.
Molly E KlugDepartment of Biological Sciences, Human and Evolutionary Biology Section, University of Southern California, Los Angeles, CA, USA.
Madhav SharmaNeuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA.
Alicia E KaoDepartment of Biological Sciences, Human and Evolutionary Biology Section, University of Southern California, Los Angeles, CA, USA.
Shan SunDepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC, USA.
Edwin D J Lopez GonzalezDepartment of Diabetes and Cancer Metabolism, Beckman Research Institute at the City of Hope, Duarte, CA, USA.
Houming ZhuMolecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Joshua C DentSchool of Biomedical Sciences, Faculty of Health, Medicine, and Behavioural Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.
Richard J ClarkSchool of Biomedical Sciences, Faculty of Health, Medicine, and Behavioural Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.
David R SellDepartment of Pathology and Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Deepitha NelsonDepartment of Pathology and Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Vincent M MonnierDepartment of Pathology and Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Linda TsanDepartment of Biological Sciences, Human and Evolutionary Biology Section, University of Southern California, Los Angeles, CA, USA.
Jessica J ReaDepartment of Biological Sciences, Human and Evolutionary Biology Section, University of Southern California, Los Angeles, CA, USA.
Arun AhujaDepartment of Biological Sciences, Human and Evolutionary Biology Section, University of Southern California, Los Angeles, CA, USA.
Natalie TaniosDepartment of Biological Sciences, Human and Evolutionary Biology Section, University of Southern California, Los Angeles, CA, USA.
Isabella GianatiempoDepartment of Biological Sciences, Human and Evolutionary Biology Section, University of Southern California, Los Angeles, CA, USA.
Mugil V ShanmugamDepartment of Biological Sciences, Human and Evolutionary Biology Section, University of Southern California, Los Angeles, CA, USA.
Yedam ParkDepartment of Biological Sciences, Human and Evolutionary Biology Section, University of Southern California, Los Angeles, CA, USA.
Kristie B YuDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Elaine Y HsiaoDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Lindsey A SchierDepartment of Biological Sciences, Human and Evolutionary Biology Section, University of Southern California, Los Angeles, CA, USA.
Anthony A FodorDepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC, USA.
Trent M WoodruffSchool of Biomedical Sciences, Faculty of Health, Medicine, and Behavioural Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0003-1382-911X
Sarah C ShuckDepartment of Diabetes and Cancer Metabolism, Beckman Research Institute at the City of Hope, Duarte, CA, USA.
Cornelius GatiMolecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Bruce E HerringNeuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA.
Melinda T CoughlanDepartment of Diabetes, School of Translational Medicine, Alfred Medical Research and Education Precinct, Monash University, Melbourne, VIC, Australia.
Scott E KanoskiDepartment of Biological Sciences, Human and Evolutionary Biology Section, University of Southern California, Los Angeles, CA, USA.

Funding

Interactions between diet and cognitionR01DK123423 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Scott Edward Kanoski · 2019 to 2026
$3.4M
Neurobiological mechanisms of Western diet-induced cognitive dysfunctionF32AG077932 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAYES, ANNA MARIE ROSE · 2022 to 2024
$185k
Neural circuits mediating food impulsive behaviorF31DK138777 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Molly e Klug · 2024 to 2026
$129k
Investigating the role of oxytocin signaling in the social regulation of eatingF31DK137484 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI REA, JESSICA · 2023 to 2024
$93k
NIA NIH HHS F32 AG077932NIDDK NIH HHS F31 DK137484NIDDK NIH HHS F31 DK138777NIDDK NIH HHS R01 DK123423
6 · The paper itself

Abstract

Consumption of processed foods is associated with dementia, obesity, and other negative health outcomes. Sustained heat treatment, a common food processing approach to enhance flavor, induces the chemical Maillard reaction that promotes the formation of dietary advanced glycation end-products (AGEs). The neurocognitive impacts of consuming dietary AGEs are poorly understood. Here we modeled an AGE-rich diet through heat treatment fed to rats during adolescence, a critical period of neural development, to mechanistically evaluate the long-term impact of early life dietary AGEs on behavioral and neural processes. Consuming the AGE-rich diet impaired hippocampal-dependent memory function and altered the gut microbiome without inducing obesity or nonspecific behavioral deficits. AGE-induced memory deficits were coupled with impaired hippocampal glutamatergic synaptic neurotransmission and altered expression in the synapse-pruning complement system. Hippocampal synaptic deficits likely result from direct AGE-complement interactions, as our extended studies reveal competitive antagonist action of AGEs on complement receptors. Memory impairments were prevented by administration of the AGE-inhibitor, alagebrium, and by supplementation with an AGE-inhibiting bacterial taxon,

Identifiers

PMID41542572
PMCPMC12803061

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.