Evidence map›Paper›PMID 41542541›Full record

ArticlebioRxiv : the preprint server for biology2026

Neuronal Toll-like Receptor-4 regulation of Matrix Metalloproteinase-9 Activity Mediates Dentate Circuit Dysfunction after Traumatic Brain Injury.

Deepak Subramanian, Erick Contreras, Laura Dovek, Razieh Jaberi, Iryna M Ethell, Vijayalakshmi Santhakumar

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Deepak SubramanianDepartment of Molecular, Cell and Systems Biology, University of California Riverside, Riverside, California 92521.ORCID 0000-0001-7109-6714
Erick ContrerasDepartment of Molecular, Cell and Systems Biology, University of California Riverside, Riverside, California 92521.
Laura DovekBiomedical Sciences, University of California Riverside, Riverside, California 92521.ORCID 0000-0002-9381-1886
Razieh JaberiDepartment of Molecular, Cell and Systems Biology, University of California Riverside, Riverside, California 92521.
Iryna M EthellBiomedical Sciences, University of California Riverside, Riverside, California 92521.ORCID 0000-0002-1324-6611
Vijayalakshmi SanthakumarDepartment of Molecular, Cell and Systems Biology, University of California Riverside, Riverside, California 92521.ORCID 0000-0001-6278-4187

Funding

Contribution of Innate Immune Receptors to Neurological Dysfunction After Traumatic Brain Injury: Mechanisms and Therapeutic ImplicationsR01NS097750 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI SANTHAKUMAR, VIJAYALAKSHMI · 2016 to 2025
$4.0M
Perisomatic Inhibitory Network Dysfunction in Neurological DiseaseR01NS069861 · NINDS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI SANTHAKUMAR, VIJAYALAKSHMI · 2011 to 2022
$3.4M
Cellular and circuit mechanisms of hippocampal dentate engram formation and seizure-induced alterationsF31NS124290 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI DOVEK, LAURA · 2021 to 2023
$126k
NINDS NIH HHS F31 NS124290NINDS NIH HHS R01 NS069861NINDS NIH HHS R01 NS097750
6 · The paper itself

Abstract

Neuroinflammatory pathways activated by traumatic brain injury (TBI) are critical mediators of long-term neurological dysfunction and represent promising therapeutic targets. Toll-like receptor 4 (TLR4), an innate immune receptor, was previously shown to contribute to seizure susceptibility and cognitive deficits in rats after lateral fluid percussion injury (FPI). However, the cellular and molecular mechanisms underlying TLR4-mediated circuit dysfunction early after brain injury is not fully understood. In this study, we define a cell- and circuit- specific neuroimmune-extracellular matrix signaling axis that mediates early post-TBI circuit dysfunction in the hippocampal Dentate Gyrus (DG). Using

Indexed as

Dentate gyrusMatrix Metalloproteinase-9Neuro-immune signalingSynaptic plasticityToll-like Receptor 4Traumatic Brain Injury

Identifiers

PMID41542541
PMCPMC12803046

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.