ArticlebioRxiv : the preprint server for biology2026
Weak pervasive incompatibilities and compensatory adaptation drive hybrid genome evolution in yeast.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Species barriers limit gene flow and maintain co-adapted genomes. Interspecific hybridization can break down species barriers to reveal genetic incompatibilities. Although the phenotypic and genomic consequences of hybridization have been extensively studied in many systems, far less is known about the longer-term evolutionary dynamics of highly divergent, mosaic genomes and the extent to which genetic incompatibilities shape their adaptation. In yeast, pre-zygotic barriers are weak but post-zygotic barriers are strong due to mispairing of chromosomes during meiosis. By suppressing anti-recombination genes in meiosis, we generated a panel of 20 haploid recombinant hybrids from a cross between
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