ArticlebioRxiv : the preprint server for biology2026
Discovery of a [4Fe-4S] cluster in the PRRSV Nsp1α leader protease reveals host-virus interplay in its downstream functions.
Trent Quist, Anastasiya Buzuk, Henry Thanh Nguyen, Ken Takeoka, Daniel W Bak, Eranthie Weerapana, Deborah L Perlstein, Maria-Eirini Pandelia
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
8 authors.
Trent QuistDepartment of Biochemistry, Brandeis University, Waltham, Massachusetts 02453, United States.
Anastasiya BuzukDepartment of Chemistry, Boston University, Boston, Massachusetts 02215, United States.
Henry Thanh NguyenDepartment of Biochemistry, Brandeis University, Waltham, Massachusetts 02453, United States.
Ken TakeokaDepartment of Biochemistry, Brandeis University, Waltham, Massachusetts 02453, United States.
Daniel W BakDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Eranthie WeerapanaDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Deborah L PerlsteinDepartment of Chemistry, Boston University, Boston, Massachusetts 02215, United States.ORCID 0000-0002-7124-9896 Maria-Eirini PandeliaDepartment of Biochemistry, Brandeis University, Waltham, Massachusetts 02453, United States.ORCID 0000-0002-6750-1948 Funding
Developing chemical-proteomic tools to investigate cysteine oxidationR35GM134964 · NIGMS · BOSTON COLLEGE · PI WEERAPANA, ERANTHIE · 2020 to 2024
$3.1MMacromolecular Structure, Dynamics, and MechanismT32GM135126 · NIGMS · BRANDEIS UNIVERSITY · PI JEFF GELLES, Douglas Lowell Theobald · 2020 to 2026
$2.1MHow does a metallofactor in Hepatitis B viral protein X orchestrate pathogenesis and liver cancerR01GM126303 · NIGMS · BRANDEIS UNIVERSITY · PI PANDELIA, MARIA-EIRINI · 2019 to 2023
$1.8MThe mechanism of apo-target recognition in cytsolic iron sulfur cluster biosynthesisR01GM121673 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI PERLSTEIN, DEBORAH L · 2018 to 2022
$1.6MFrom humans and eukaryotes to viruses and pathogens; how transition metals shape catalysis and allosteryR35GM156452 · NIGMS · BRANDEIS UNIVERSITY · PI Maria-Eirini Pandelia · 2025 to 2026
$935kNIGMS NIH HHS R01 GM121673NIGMS NIH HHS R01 GM126303NIGMS NIH HHS R35 GM134964NIGMS NIH HHS R35 GM156452NIGMS NIH HHS T32 GM135126
6 · The paper itselfAbstract
Porcine reproductive and respiratory syndrome virus (PRRSV;
Indexed as
chemoproteomicscytosolic Fe-S cluster assemblyEPRFe-S clusterMössbauerviral protease
Identifiers
PMID41542491
PMCPMC12803254
What OpenQuestion holds
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