Evidence map›Paper›PMID 41542480›Full record

ArticlebioRxiv : the preprint server for biology2026

Nvj3 regulates Dga1-mediated triacylglycerol synthesis and lipid droplet formation at ER contact sites.

Daniel Adebayo, Eseiwi Obaseki, Scott Miller, Marwa Aboumourad, Zaid Saadeh, Zachary Pomicter, Lindsey Kreinbring, Mohamad Rahal, Kashvi Vasudeva, Garrett Frost and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Daniel AdebayoBiological Sciences Department, Wayne State University, Detroit, MI, USA.
Eseiwi ObasekiBiological Sciences Department, Wayne State University, Detroit, MI, USA.
Scott MillerBiological Sciences Department, Wayne State University, Detroit, MI, USA.
Marwa AboumouradBiological Sciences Department, Wayne State University, Detroit, MI, USA.
Zaid SaadehBiological Sciences Department, Wayne State University, Detroit, MI, USA.
Zachary PomicterBiological Sciences Department, Wayne State University, Detroit, MI, USA.
Lindsey KreinbringBiological Sciences Department, Wayne State University, Detroit, MI, USA.
Mohamad RahalBiological Sciences Department, Wayne State University, Detroit, MI, USA.
Kashvi VasudevaBiological Sciences Department, Wayne State University, Detroit, MI, USA.
Garrett FrostBiological Sciences Department, Wayne State University, Detroit, MI, USA.
Reema SmadiBiological Sciences Department, Wayne State University, Detroit, MI, USA.
Hanaa HaririBiological Sciences Department, Wayne State University, Detroit, MI, USA.ORCID 0009-0008-4044-9597

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI Julie Lynn Boerner · 1985 to 2026
$68.4M
Subcellular mechanisms coupling lipid synthesis and methionine metabolismR35GM150892 · NIGMS · WAYNE STATE UNIVERSITY · PI Hanaa Hariri · 2023 to 2026
$1.5M
NCI NIH HHS P30 CA022453NIGMS NIH HHS R35 GM150892
6 · The paper itself

Abstract

Lipid droplet (LD) biogenesis is essential for lipid homeostasis during nutrient stress, yet how lipid intermediates are spatially organized to support efficient triacylglycerol (TAG) synthesis remains unclear. Here, we identify Nvj3 as a nutrient-responsive regulator that links diacylglycerol (DAG) availability to TAG synthesis and LD formation at the endoplasmic reticulum (ER). Nvj3 is induced by glucose depletion and recruited to LD-associated ER domains. Loss of Nvj3 causes neutral lipid accumulation under steady state conditions but delays TAG synthesis under acute inducible metabolic transitions. Using controlled TAG induction systems, we show that Nvj3 is required to couple Dga1-dependent TAG synthesis to LD formation. In the absence of Nvj3, TAG accumulates but remains inefficiently packaged into LDs. Consistent with this defect,

Identifiers

PMID41542480
PMCPMC12803121

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.