Evidence map›Paper›PMID 41542474›Full record

ArticlebioRxiv : the preprint server for biology2026

High-throughput mapping of 6,888

Kristie E Darrah, Shelby L Hemker, Yashpal Rawal, Noah J Goff, Phoebe Parker, Gayatri Ganesan, Caleb M Stratton, Katherine Oppenheimer, Ella Roberts, Elena Glick and 11 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Kristie E DarrahDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Shelby L HemkerDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Yashpal RawalDepartment of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Noah J GoffDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Phoebe ParkerDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Gayatri GanesanDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Caleb M StrattonDepartment of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Katherine OppenheimerDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Ella RobertsDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Elena GlickDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Nicole BanksDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Arjun KumarDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Silvia CasadeiDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Matthew W SnyderDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Katherine NathansonDepartment of Medicine, Basser Center for BRCA, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Susan M DomchekDepartment of Medicine, Basser Center for BRCA, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Lea M StaritaDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Shaun K OlsenDepartment of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Patrick SungDepartment of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Jacob O KitzmanDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Kara A BernsteinDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI A. Clementina Mesaros · 2006 to 2026
$35.3M
Regulation of BRCA-dependent Genome Repair via the 53BP1 AxisP01CA275717 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DAVID STEVEN LIBICH · 2024 to 2026
$10.1M
Translational Research Training Program in Environmental Health SciencesT32ES019851 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Kara A Bernstein, Trevor M Penning · 2012 to 2026
$6.0M
Mechanisms of DNA Homology-directed Genome Repair and Tumor SuppressionR35CA241801 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SUNG, PATRICK · 2019 to 2025
$6.0M
Replication fork dynamics and repair by Rad51 paralogues after DNA alkylationR01ES030335 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Kara A Bernstein · 2019 to 2026
$2.9M
Structural Biology of the Ubiquitin Conjugation SystemR01GM115568 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI OLSEN, SHAUN · 2015 to 2023
$2.7M
Structure and Function of the Essential Cell Cycle Regulator Cdc34R01GM128731 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Shaun Olsen · 2019 to 2026
$2.5M
RAD51 paralog function in cancer predisposition and genome integrity    R01ES031796 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BERNSTEIN, KARA A · 2021 to 2025
$2.2M
Structure and function of RAD51 paralog tumor suppressor complexes in genome maintenanceR01CA293655 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Eric C Greene, Shaun Olsen · 2024 to 2026
$1.9M
Expanding the Reach of Massively Parallel Variant Effect ScreensR35GM153286 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jacob Otto Kitzman · 2024 to 2026
$1.5M
NCI NIH HHS P01 CA275717NCI NIH HHS R01 CA293655NCI NIH HHS R35 CA241801NIEHS NIH HHS P30 ES013508NIEHS NIH HHS R01 ES030335NIEHS NIH HHS R01 ES031796NIEHS NIH HHS T32 ES019851NIGMS NIH HHS R01 GM115568NIGMS NIH HHS R01 GM128731NIGMS NIH HHS R35 GM153286
6 · The paper itself

Abstract

The tumor suppressor

Indexed as

BCDX2Homologous RecombinationMultiplex Assay of Variant EffectRAD51RAD51DRAD51 ParalogVariants of Unknown SignificanceX3CDX2XRCC3 complex

Identifiers

PMID41542474
PMCPMC12803133

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.