Evidence map›Paper›PMID 41542460›Full record

ArticlebioRxiv : the preprint server for biology2026

Maternal lipids prime quiescent neural stem cells to reactivate in response to dietary nutrients.

Md Ausrafuggaman Nahid, Susan E Doyle, Kelly E Dunham, Michelle L Bland, Sarah E Siegrist

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Md Ausrafuggaman NahidDepartment of Biology, University of Virginia, Charlottesville, VA 22904, USA.
Susan E DoyleDepartment of Biology, University of Virginia, Charlottesville, VA 22904, USA.
Kelly E DunhamDepartment of Pharmacology, School of Medicine, University of Virginia, Charlottesville, VA 22904, USA.
Michelle L BlandDepartment of Pharmacology, School of Medicine, University of Virginia, Charlottesville, VA 22904, USA.
Sarah E SiegristDepartment of Biology, University of Virginia, Charlottesville, VA 22904, USA.

Funding

Research Training in Neuroendocrinology and MetabolismT32DK007646 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI ZHENQI LIU · 1990 to 2026
$4.9M
Nutrient-dependent regulation of neural stem cell proliferation and neural circuit formationR35GM141886 · NIGMS · UNIVERSITY OF VIRGINIA · PI SIEGRIST, SARAH ELIZABETH · 2021 to 2025
$2.3M
Signaling mechanisms linking infection, endocrine dysfunction, and growth failureR01DK123433 · NIDDK · UNIVERSITY OF VIRGINIA · PI BLAND, MICHELLE L · 2021 to 2024
$1.6M
NIDDK NIH HHS R01 DK123433NIDDK NIH HHS T32 DK007646NIGMS NIH HHS R35 GM141886
6 · The paper itself

Abstract

Stem cell quiescence--a state of mitotic and metabolic dormancy--is essential for tissue homeostasis and for coordinating growth with nutrient availability. Switching between quiescence and proliferation is controlled through stem cell intrinsic and extrinsic cues, with diet being key as diet provides macro- and micro-nutrients needed for synthesizing new membrane, protein, and nucleic acids. Yet, it remains unclear what nutrients control the stem cell switch and whether nutrient sources other than diet are required. Here, we report that lipids deposited maternally in the embryo regulate reactivation of

Identifiers

PMID41542460
PMCPMC12803041

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.