Evidence map›Paper›PMID 41542459›Full record

ArticlebioRxiv : the preprint server for biology2026

Hookworm genomic diversity and population structure from accessible sample types: A validated approach to generate genome-wide polymorphism datasets from individual third-stage larvae.

Kaylee S Herzog, Savanna Randi, Dickson Osabutey, Christina Paraggio, Richard Bungiro, Lisa Harrison, Irene Owusu Donkor, Francis Appiah-Tsum, Amanda Lamptey, Isaac Quaye and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kaylee S HerzogDepartment of Biology and Museum of Southwestern Biology, University of New Mexico, Albuquerque, NM, USA.ORCID 0000-0002-6777-6722
Savanna RandiEpidemiology of Microbial Diseases Department, Yale School of Public Health, New Haven, CT, USA.
Dickson OsabuteyDepartment of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Christina ParaggioEpidemiology of Microbial Diseases Department, Yale School of Public Health, New Haven, CT, USA.
Richard BungiroEpidemiology of Microbial Diseases Department, Yale School of Public Health, New Haven, CT, USA.
Lisa HarrisonDepartment of Pediatrics, Yale School of Medicine, New Haven, CT, USA.
Irene Owusu DonkorDepartment of Epidemiology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.ORCID 0000-0002-8523-955X
Francis Appiah-TsumDepartment of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Amanda LampteyDepartment of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Isaac QuayeDepartment of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Shaelynn VaughanDepartment of Biology, Rockhurst University, Kansas City, MO, USA.
Michael D WilsonDepartment of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Anita GhansahDepartment of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Michael CappelloEpidemiology of Microbial Diseases Department, Yale School of Public Health, New Haven, CT, USA.
Joseph R FauverDepartment of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0001-8099-2991

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Translational studies of hookworm infection in GhanaR01AI162826 · NIAID · YALE UNIVERSITY · PI MICHAEL CAPPELLO · 2022 to 2026
$3.8M
Genomic approaches to define hookworm population diversity and deworming drug responseR01AI182301 · NIAID · YALE UNIVERSITY · PI MICHAEL CAPPELLO · 2024 to 2026
$2.2M
High Performance Computing Instrumentation for the Yale Center for Genome AnalysisS10OD030363 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2022 to 2022
$1.2M
NCATS NIH HHS UL1 TR001863NIAID NIH HHS R01 AI162826NIAID NIH HHS R01 AI182301NIH HHS S10 OD030363
6 · The paper itself

Abstract

Hookworm infection is a neglected tropical disease affecting hundreds of thousands of people annually in the tropics and sub-tropics. Population genomic approaches have the potential to improve our understanding of hookworm infection dynamics and control efficacy. Here, we validate an approach to generate genome-wide polymorphism datasets from accessible sample types in the zoonotic hookworm (

Identifiers

PMID41542459
PMCPMC12803160

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.