Evidence map›Paper›PMID 41542406›Full record

ArticlebioRxiv : the preprint server for biology2026

Cribriform Plate Microenvironment Assembles a Suppressive Myeloid Network during EAE-induced Neuroinflammation.

Collin Laaker, Martin Hsu, Andy Madrid, Jenna Port, Sophia M Vrba, Melinda Herbath, Cameron Baenen, Mohan Kumar, Thanthrige Thiunuwan Priyathilaka, Matyas Sandor and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Collin LaakerNeuroscience Training Program, University of Wisconsin Madison, Madison WI 53705, USA.ORCID 0000-0001-8532-9427
Martin HsuDepartment of Microbiology-Immunology, University of North Carolina at Chapel Hill, NC, 27599.
Andy MadridNeuroscience Training Program, University of Wisconsin Madison, Madison WI 53705, USA.
Jenna PortDepartment of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin Madison, Madison WI 53705, USA.
Sophia M VrbaDepartment of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin Madison, Madison WI 53705, USA.
Melinda HerbathDepartment of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin Madison, Madison WI 53705, USA.
Cameron BaenenDepartment of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin Madison, Madison WI 53705, USA.
Mohan KumarDepartment of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin Madison, Madison WI 53705, USA.
Thanthrige Thiunuwan PriyathilakaDepartment of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin Madison, Madison WI 53705, USA.
Matyas SandorDepartment of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin Madison, Madison WI 53705, USA.
Zsuzsanna FabryDepartment of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin Madison, Madison WI 53705, USA.

Funding

Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
Neuroscience Training ProgramT32NS105602 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Ari Rosenberg · 2019 to 2026
$2.5M
Regulation of Neuroinflammation by Meningeal LymphaticsR01NS126595 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Zsuzsanna Fabry · 2022 to 2026
$2.3M
Graduate Training in Cellular and Molecular Pathogenesis of Human DiseasesT32GM135119 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Zsuzsanna Fabry · 2020 to 2026
$2.2M
The role of lymphatic clearance in brain TBR01NS123449 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Matyas Sandor · 2022 to 2026
$2.0M
NIGMS NIH HHS T32 GM135119NIGMS NIH HHS T32 GM140935NINDS NIH HHS R01 NS123449NINDS NIH HHS R01 NS126595NINDS NIH HHS T32 NS105602
6 · The paper itself

Abstract

During neuroinflammation, CD11c+CD11b+ myeloid cells accumulate at the cribriform plate, a key cerebrospinal fluid (CSF) and antigen outflow site in mice. At this site, podoplanin (PDPN)-expressing cells, including lymphatic vessels and meningeal layers, expand to create a distinct drainage microenvironment. In this study we sought to characterize myeloid cells which populate this region using a mouse model of neuroinflammation, experimental autoimmune encephalomyelitis (EAE). Utilizing a combination of immunohistochemistry, flow cytometry, and scRNAseq, we report that macrophages and dendritic cells (DCs) from this region display unique expressional signatures related to tolerance, cell death, and reduced inflammatory profile. Together this data supports that myeloid retention at the cribriform plate and olfactory bulb meninges promotes a local immunosuppressive environment.

Identifiers

PMID41542406
PMCPMC12803268

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.