Evidence map›Paper›PMID 41542402›Full record

ArticlebioRxiv : the preprint server for biology2026

Dual Inhibition of MYRF Cleavage by Its JM Region and PAN-1 CCT Gates Developmental Timing in

Zhimin Xu, Xiaoting Feng, Haochen Lyu, Yong-Hong Yan, Yongqi Zhou, Zhizhi Wang, Fang Bai, Meng-Qiu Dong, Yingchuan B Qi

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhimin XuSchool of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.ORCID 0009-0007-6371-9345
Xiaoting FengSchool of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Haochen LyuSchool of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Yong-Hong YanNational Institute of Biological Sciences, Beijing, 102206, China.
Yongqi ZhouSchool of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Zhizhi WangSchool of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Fang BaiSchool of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Meng-Qiu DongNational Institute of Biological Sciences, Beijing, 102206, China.ORCID 0000-0002-6094-1182
Yingchuan B QiSchool of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.ORCID 0000-0002-4267-4770

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Post-embryonic development proceeds through discrete stages, yet the mechanisms that coordinate transitions between stages remain incompletely defined. The transmembrane transcription factor MYRF undergoes intramolecular cleavage to release a nuclear-localized fragment essential for developmental progression in

Indexed as

Caenorhabditis elegansdevelopmental timinglarval stage transitionMYRF-1nutrient signalingPAN-1proteolytic cleavagetranscriptional regulation

Identifiers

PMID41542402
PMCPMC12803276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.