Evidence map›Paper›PMID 41542394›Full record

ArticlebioRxiv : the preprint server for biology2026

Novel genes arise from genomic deletions across the bacterial tree of life.

Arya Kaul, Fernando Rossine, Karel Břinda, Michael Baym

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Arya KaulDepartments of Biomedical Informatics and Microbiology, and Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.ORCID 0000-0001-8382-5945
Fernando RossineDepartments of Biomedical Informatics and Microbiology, and Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.ORCID 0000-0002-6481-5845
Karel BřindaInria, Irisa, Univ. Rennes, 35042 Rennes, France.ORCID 0000-0003-0200-557X
Michael BaymDepartments of Biomedical Informatics and Microbiology, and Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.ORCID 0000-0003-1303-5598

Funding

Evolutionary Tradeoffs in Antibiotic ResistanceR35GM133700 · NIGMS · HARVARD MEDICAL SCHOOL · PI BAYM, MICHAEL · 2019 to 2023
$2.4M
Evolutionary Tradeoffs in Antibiotic ResistanceR35GM156320 · NIGMS · HARVARD MEDICAL SCHOOL · PI Michael Baym · 2025 to 2026
$967k
NIGMS NIH HHS R35 GM133700NIGMS NIH HHS R35 GM156320
6 · The paper itself

Abstract

Bacteria are hosts to enormous genic diversity. How new genes emerge, functionalize, and spread remain longstanding questions. Here, we explore a mechanism by which adaptive deletions fuse distant gene fragments. Unlike other gene birth mechanisms that begin with rare, neutral mutations, these "deletion-born fusions" reach high frequency by hitch-hiking on the deletion. The deletion-driven proliferation of the fusion prolongs the mutational supply within these genes before loss, providing additional opportunities for neofunctionalization. We document one such gene fixing and expressing in a long-term

Indexed as

bacterial gene birthgenomic deletionsstructural variation

Identifiers

PMID41542394
PMCPMC12803068

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.