Evidence map›Paper›PMID 41542349›Full record

ArticleJournal of Taibah University Medical Sciences2026

In silico evaluation of

Muhammad I Rizal, Syafia Husain, Komariah Komariah, Ciptadhi T Binartha, Arief Cahyanto, Moehamad O Roeslan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Taibah University Medical Sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Muhammad I RizalDepartment of Oral Biology, Faculty of Dentistry, Universitas Trisakti, Jakarta, Indonesia.
Syafia HusainCenter of Molecular Biology Study, Faculty of Dentistry, Universitas Trisakti, Jakarta, Indonesia.
Komariah KomariahDepartment of Oral Biology, Faculty of Dentistry, Universitas Trisakti, Jakarta, Indonesia.
Ciptadhi T BinarthaDepartment of Oral Biology, Faculty of Dentistry, Universitas Trisakti, Jakarta, Indonesia.
Arief CahyantoDepartment of Clinical Sciences, College of Dentistry, Ajman University, Ajman, United Arab Emirates.
Moehamad O RoeslanDepartment of Oral Biology, Faculty of Dentistry, Universitas Trisakti, Jakarta, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Methods: Molecular docking was performed with validation by redocking and confirmation of receptor reliability (RMSD 1.821 Å for HmuY and 0.851 Å for FhbB). Chlorhexidine and minocycline were included as positive controls. Binding energies (ΔG), inhibition constants (Ki), and receptor-ligand interactions were analyzed. Results: Echitamine chloride exhibited the strongest affinity for HmuY (ΔG -4.86 kcal/mol; Ki 274.96 μM), whereas alstonine bound most strongly to FhbB (ΔG -7.44 kcal/mol; Ki 3.53 μM). Villalstonine showed moderate affinity, whereas minocycline was the most potent overall. Key hydrogen bonds involved ARG178, TRP70, and TYR116. Conclusions:

Indexed as

Alstonia scholarisMolecular dockingPeriodontal pathogensPorphyromonas gingivalisTreponema denticola

Identifiers

PMID41542349
PMCPMC12803827

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.