Evidence map›Paper›PMID 41542286›Full record

ArticleCardiovascular therapeutics2026

Aldehyde Dehydrogenase-2 Alleviates Septic Myocardial Injury by Inhibiting Caspase-11-Mediated Noncanonical Pyroptosis.

Huan Liang, Yuying He, Yiren Wang, Rui Zhang, Mengjie Yu, Hongwei Ye, JiaHui Wang, Qin Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huan LiangKey Laboratory of Cardiovascular and Cerebrovascular Diseases, Bengbu Medical University, Bengbu, Anhui, China, bbmc.edu.cn.ORCID https://orcid.org/0000-0002-2757-750X
Yuying HeKey Laboratory of Cardiovascular and Cerebrovascular Diseases, Bengbu Medical University, Bengbu, Anhui, China, bbmc.edu.cn.
Yiren WangKey Laboratory of Cardiovascular and Cerebrovascular Diseases, Bengbu Medical University, Bengbu, Anhui, China, bbmc.edu.cn.
Rui ZhangKey Laboratory of Cardiovascular and Cerebrovascular Diseases, Bengbu Medical University, Bengbu, Anhui, China, bbmc.edu.cn.
Mengjie YuKey Laboratory of Cardiovascular and Cerebrovascular Diseases, Bengbu Medical University, Bengbu, Anhui, China, bbmc.edu.cn.
Hongwei YeKey Laboratory of Cardiovascular and Cerebrovascular Diseases, Bengbu Medical University, Bengbu, Anhui, China, bbmc.edu.cn.ORCID https://orcid.org/0000-0002-5201-926X
JiaHui WangDepartment of Physiology, Bengbu Medical University, Bengbu, Anhui, China, bbmc.edu.cn.ORCID https://orcid.org/0000-0002-5876-5861
Qin GaoKey Laboratory of Cardiovascular and Cerebrovascular Diseases, Bengbu Medical University, Bengbu, Anhui, China, bbmc.edu.cn.ORCID https://orcid.org/0000-0002-7599-4295

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: The purpose of this study is to investigate the role of aldehyde dehydrogenase-2 (ALDH2) in septic myocardial injury, focusing on noncanonical pyroptosis. Methods: In vivo, C57BL/6J mice were divided into five groups: Sham, cecal ligation and puncture (CLP), CLP + Alda-1 (ALDH2 agonist), Sham + dimethyl sulfoxide (DMSO, solvent control), and CLP + DMSO. Cardiac function and histological/ultrastructural changes were assessed via echocardiography, hematoxylin-eosin (HE) staining, and transmission electron microscopy (TEM). Tumor necrosis factor- Results: In vivo, Alda-1 significantly attenuated CLP-induced cardiac dysfunction and reduced myocardial histological damage and ultrastructural impairment. In vitro, ALDH2 overexpression lowered LPS-induced H9C2 cell viability, CK-MB, and LDH release. Upregulating ALDH2 significantly reduced caspase-11, HMGB1, and RAGE expression. CO-IP showed ALDH2 interacted with HMGB1, RAGE, and GSDMD. Conclusion: ALDH2 protects the myocardium from septic injury by inhibiting caspase-11-mediated noncanonical pyroptosis, possibly via direct interactions with GSDMD, HMGB1, and RAGE.

Indexed as

Aldehyde Dehydrogenase, MitochondrialBenzamidesBenzodioxolesCaspases, InitiatorMyocardiumMyocytes, CardiacPyroptosisSepsisAnimalsCell LineDisease Models, AnimalGasderminsIntracellular Signaling Peptides and ProteinsMaleMice, Inbred C57BLPhosphate-Binding ProteinsAldehyde Dehydrogenase, MitochondrialALDH2 protein, mouseBenzamidesBenzodioxolesCasp4 protein, mouseCaspases, InitiatorGasderminsGsdmd protein, mouseIntracellular Signaling Peptides and ProteinsN-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamidePhosphate-Binding Proteinsaldehyde dehydrogenase-2caspase-11gasdermin-Dnoncanonical pyroptosissepsis

Identifiers

PMID41542286
PMCPMC12800742

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.