ArticleJournal of anaesthesiology, clinical pharmacology
A randomized controlled trial evaluating the efficacy of combined dexamethasone and dexmedetomidine as adjuvants to ropivacaine in adductor canal block for postoperative analgesia in total knee arthroplasty.
Article in Journal of anaesthesiology, clinical pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Dexamethasone vs. Dexmedetomidine as Adjuvants to Erector Spinae Plane Block in Total Knee Arthroplasty: A Randomized Double-Blind Controlled Trial.Journal of clinical medicine · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: This prospective, randomized, double-blind controlled trial investigated whether adding perineural dexamethasone and dexmedetomidine to ropivacaine in adductor canal block (ACB) improves postoperative analgesia compared to using only perineural dexamethasone with ropivacaine in patients undergoing total knee arthroplasty (TKA). Material and Methods: Fifty-eight patients undergoing TKA received ultrasound-guided ACB (30 mL of 0.5% ropivacaine). They were randomly assigned to receive either perineural dexamethasone (4 mg) or a combination of perineural dexamethasone (4 mg) and dexmedetomidine (50 mcg), with 29 participants in each group. A blinded observer assessed the primary outcome: morphine consumption in the first 24 postoperative hours. Secondary outcomes included total 48-hour morphine consumption, postoperative pain scores (NRS) at rest and during movement, quadriceps muscle strength, timed up and go (TUG) test time, Ramsay sedation score, and incidence of nausea, vomiting, hypotension, bradycardia, and desaturation. Results: The dexamethasone-dexmedetomidine group showed significantly lower 24-hour (14.38 ± 5.68 mg vs. 8.55 ± 4.37 mg, Conclusion: The study suggests that adding dexamethasone and dexmedetomidine to ropivacaine for ACB may significantly improve postoperative pain relief in TKA patients without causing harmful side effects.
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