ArticleJournal of anaesthesiology, clinical pharmacology
Effect of different doses of intrathecal morphine on postoperative fentanyl consumption in open live donor hepatectomy - A double-blind, randomized controlled trial.
Article in Journal of anaesthesiology, clinical pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aims: Intrathecal morphine (ITM) has been widely used to provide effective postoperative analgesia. This study aims to compare the efficacy and safety of three different doses of ITM - 200, 300, and 400 μg - in patients undergoing open donor hepatectomy. Material and Methods: A total of 90 patients were randomized into three groups (30 patients each) receiving either 200 μg (Group A), 300 μg (Group B), or 400 μg (Group C) of ITM, along with 5 mg of 0.5% bupivacaine. Postoperative pain was managed using intravenous patient-controlled analgesia with fentanyl. Total fentanyl consumption, visual analog scale (VAS) scores, Ramsay Sedation Scale score, and incidence of side effects were recorded for 72 h postoperatively. Data was analyzed using the Student's Results: Cumulative postoperative fentanyl consumption at 24 h was similar across all three groups: Group A (100 [50-200] μg), Group B (100 [50-225] μg), and Group C (100 [50-231] μg) ( Conclusions: A dose of 200 μg of ITM provides effective postoperative pain control in patients undergoing open live donor hepatectomy and results in fewer opioid-related side effects, compared to 300 and 400 μg doses.
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