Evidence map›Paper›PMID 41542108›Full record

ArticleGeburtshilfe und Frauenheilkunde2026

Time Toxicity of Endocrine-based Oral CDK4/6 Inhibitor Therapies.

Henning Schäffler, Sabine Heublein, Julia Lichtblau, Lisa Wisniewski, Brigitte Rack, Wolfgang Janni, Alexander Englisch, Johannes Englisch, Tobias Engler, Andreas Hartkopf and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Geburtshilfe und Frauenheilkunde, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Time toxicity in cancer care: a systematic review of definitions and measurement methods.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Henning SchäfflerDepartment of Gynecology and Obstetrics, University Clinic Ulm, Ulm, Germany.
Sabine HeubleinDepartment of Gynecology and Obstetrics, University Clinic Ulm, Ulm, Germany.
Julia LichtblauDepartment of Gynecology and Obstetrics, University Clinic Ulm, Ulm, Germany.
Lisa WisniewskiDepartment of Gynecology and Obstetrics, University Clinic Ulm, Ulm, Germany.
Brigitte RackDepartment of Gynecology and Obstetrics, University Clinic Ulm, Ulm, Germany.
Wolfgang JanniDepartment of Gynecology and Obstetrics, University Clinic Ulm, Ulm, Germany.
Alexander EnglischDepartment of Women's Health, Tuebingen University Hospital, Tübingen, Germany.
Johannes EnglischDepartment of Women's Health, Tuebingen University Hospital, Tübingen, Germany.
Tobias EnglerDepartment of Women's Health, Tuebingen University Hospital, Tübingen, Germany.
Andreas HartkopfDepartment of Women's Health, Tuebingen University Hospital, Tübingen, Germany.
Sara BruckerDepartment of Women's Health, Tuebingen University Hospital, Tübingen, Germany.
Lisbeth HilmerDepartment of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
Franziska FickDepartment of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
Fabian KohlsDepartment of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
Maggie Banys-PaluchowskiDepartment of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
Achim RodyDepartment of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
Dominik DannehlDepartment of Women's Health, Tuebingen University Hospital, Tübingen, Germany.
Nikolas TauberDepartment of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.ORCID 0009-0001-4592-2151

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adjuvant endocrine therapy with CDK4/6 inhibitors necessitates regular visits, lab assessments and side effect management, currently conducted primarily at breast cancer centers in Germany. This retrospective analysis estimates the potential travel distances, times and CO

Indexed as

breast cancerCDK 4/6 inhibitorsoncologyoral cancer therapysystemic therapytime toxicity

Identifiers

PMID41542108
PMCPMC12803762

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.