Evidence map›Paper›PMID 41542097›Full record

ArticleJournal of orthopaedic translation2025

Multi-scale biomimetic fusion construction of cerium ion hydrogel-scaffold for promoting osteoporotic bone defect repair.

Yesheng Jin, Shuqing Lv, Nanning Lv, Yixue Huang, Jia Wang, Yun Xiao, Xinfeng Zhou, Yanxia Ma, Gang Zhao, Fan He and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic translation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Bone organoids and mitochondrial reprogramming.Journal of orthopaedic translation · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yesheng JinDepartment of Orthopedic, The First Affiliated Hospital of Soochow University, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, 215000, Jiangsu, China.
Shuqing LvMOE Key Laboratory of Geriatric Diseases and Immunology, School of Life Science, Suzhou Medical College, Soochow University, Suzhou, 215000, China.
Nanning LvDepartment of Orthopedic Surgery, Lianyungang Clinical College, Xuzhou Medical University & The Second People's Hospital of Lianyungang, 41 Hailian East Street, Lianyungang, Jiangsu, 222003, China.
Yixue HuangDepartment of Orthopedic, The First Affiliated Hospital of Soochow University, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, 215000, Jiangsu, China.
Jia WangMOE Key Laboratory of Geriatric Diseases and Immunology, School of Life Science, Suzhou Medical College, Soochow University, Suzhou, 215000, China.
Yun XiaoDepartment of Orthopedic, The First Affiliated Hospital of Soochow University, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, 215000, Jiangsu, China.
Xinfeng ZhouDepartment of Orthopedic, The First Affiliated Hospital of Soochow University, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, 215000, Jiangsu, China.
Yanxia MaDepartment of Orthopedic, The First Affiliated Hospital of Soochow University, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, 215000, Jiangsu, China.
Gang ZhaoDepartment of Orthopedic, Soochow University Affiliated Wuxi Ninth People's Hospital, Wuxi, 214061, China.
Fan HeDepartment of Orthopedic, The First Affiliated Hospital of Soochow University, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, 215000, Jiangsu, China.
Yong XuDepartment of Orthopedic, The First Affiliated Hospital of Soochow University, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, 215000, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The treatment of bone defects in the context of osteoporosis encounters numerous challenges. In the osteoporotic microenvironment, bone resorption outweighs bone formation, impeding the self-repair of bone defect areas. Furthermore, the deterioration of osteogenesis-angiogenesis coupling function at the defect sites and excessive inflammatory responses further complicate the treatment of bone defects. Hence, an improved approach is urgently needed to enhance the treatment of osteoporotic bone defects. Methods: Our efficient strategy has developed a multi-scale biomimetic fusion alendronate sodium cerium ion hydrogel scaffold, integrating 3D-printed tricalcium phosphate (TCP) scaffolds, collagen-methacrylate (COMA) hydrogel, and nanoparticles of alendronate sodium cerium ions. Results: The results demonstrated that Conclusion: We create a hydrogel scaffold that not only offers adequate mechanical support but also possesses a favorable microenvironment for cell growth and contains biological factors promoting osteogenic and angiogenic differentiation. The translational potential of this paper: This application represents a pioneering aspect of multi-scale biomimetic hydrogel scaffolds in addressing osteoporotic bone defects, providing a novel direction for the treatment of osteoporotic bone defects.

Indexed as

AlendronateBone regenerationCalcium ion transportCeriumOsteoporotic bone defectWnt pathway

Identifiers

PMID41542097
PMCPMC12799519

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.