ArticleComputational and structural biotechnology journal2025
Plasma cell-free extrachromosomal circular DNA is a molecular hallmark of preeclampsia.
Article in Computational and structural biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Discovery and validation of GNA12Frontiers in neurology · 2026Article
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12 authors.
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Abstract
Background: Extrachromosomal circular DNA (eccDNA) is emerging as a novel biomarker for multiple diseases, but its role in reproductive diseases remains underexplored. Preeclampsia (PE) is associated with increased maternal and perinatal morbidity and mortality. Identifying new screening biomarkers may improve PE-affected pregnancies' outcomes. Methods: To investigate eccDNAs in PE, we collected plasma biopsies from 24 PE-affected and 23 normotensive (Norm) pregnancies, including 14 paired samples collected before and after diagnosis. eccDNA was profiled through linear DNA removal, circular DNA enrichment, and sequencing. The reliability of eccDNA detection was validated using Integrative Genomics Viewer plots and Sanger sequencing. Results: Our analysis identified significantly more eccDNAs in the plasma of PE-affected pregnancies than that in Norm pregnancies (p = 1.67 × 10 Conclusions: This study presents the first eccDNA landscape in the plasma of PE and indicates that plasma eccDNA may serve as a distinguishing hallmark between PE-affected and Norm pregnancies.
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