Evidence map›Paper›PMID 41542058›Full record

ArticleResearch square2026

CD38 Inhibition Ameliorates Age-Related CognitiveDecline via a Choroid Plexus-Cerebrospinal Fluid-Hippocampus Axis.

Eric Verdin, Jingqi Fang, Rebeccah Riley, Kevin Schneider, Rosalba Perrone, Prasanna Kumaar, Christina King, Grant Kauwe, Andrea Roberts, Genesis Vega Hormazabal and 18 more

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Eric VerdinBuck Institute for Research on Aging.ORCID 0000-0003-3703-3183
Jingqi FangBuck Institute for Research on Aging.ORCID 0000-0002-5733-4373
Rebeccah RileyBuck Institute Research on Aging.ORCID 0000-0002-5870-6837
Kevin SchneiderBuck Institute.ORCID 0009-0001-8046-0167
Rosalba PerroneBuck Institute for Research on Aging.
Prasanna KumaarBuck Institute for Research on Aging.
Christina KingBuck Institute for Research on Aging.
Grant KauweBuck Institute for Research on Aging.
Andrea RobertsBuck Institute for Research on Aging.
Genesis Vega HormazabalBuck Institute for Research on Aging.
Yini ZhangBuck Institute for Research on Aging.
Ethan MillardBuck Institute for Research on Aging.ORCID 0009-0000-5944-9855
Xinran LiuBuck Institute for Research on Aging.
Wendy JaraBuck Institute for Research on Aging.
Carlos Galicia AguirreBuck Institute for Research on Aging.
Harrison BakerBuck Institute for Research on Aging.
Natalia MuradBuck Institute for Research on Aging.
Ben AmbroseBuck Institute for Research on Aging.
Tommy TranBuck Institute for Research on Aging.
Nicolas MartinBuck Institute for Research on Aging.
Durai SellegounderBuck Institute for Research on Aging.
Simon MelovBuck Institute for Research on Aging.ORCID 0000-0001-8554-2834
David FurmanBuck Institute for Research on Aging.ORCID 0000-0002-3654-9519
Tara TracyBuck Institute.ORCID 0000-0003-3356-4091
Akos GerencserBuck Institute.
Birgit SchillingBuck Institute for Research on Aging.ORCID 0000-0001-9907-2749
Lisa EllerbyBuck Institute for Research on Aging.ORCID 0000-0002-9050-7977

Funding

Single cell analysis coreP01AG066591 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI MELOV, SIMON · 2021 to 2025
$15.5M
Training in Basic Research on Aging and Age-Related DiseaseT32AG000266 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Lisa M Ellerby · 1998 to 2026
$13.8M
Resilience pathways modeling human longevity-promoting ApoE variants in induced pluripotent stem cellsR01AG061879 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI ELLERBY, LISA M, MELOV, SIMON · 2018 to 2022
$4.4M
NIA NIH HHS P01 AG066591NIA NIH HHS R01 AG061879NIA NIH HHS T32 AG000266
6 · The paper itself

Abstract

Age-related cognitive decline represents a major and unresolved challenge of human aging. Here, we identify the NAD

Identifiers

PMID41542058
PMCPMC12803333

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.