ArticleResearch square2026
Neural Correlates of Mentalizing Altered in Childhood Trauma and Cocaine Use Disorder.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Childhood trauma is highly prevalent among individuals with cocaine use disorder (iCUD), and both entail social cognition deficits, including impaired mentalizing (social inference) capacity. Here we sought to examine the neuro-circuits underlying these associations using task-based neuroimaging. We hypothesized that childhood trauma and CUD would show altered brain activation of the mentalizing network, related to deficits in real-world social capacities. Methods: Participants (45 iCUD and 34 healthy controls (HC), with high/low trauma) performed the validated Why/How fMRI task, probing Results: Mentalizing task behavior outcomes were worse in iCUD than HC (F Conclusion: Greater frontal activation in high-trauma individuals may support task accuracy but is linked to poorer real-world social functioning. Additionally, the link between CUD diagnosis and precuneus activity depends on trauma severity, offering neural insights into how trauma history may influence CUD and social function.
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