Evidence map›Paper›PMID 41542053›Full record

ArticleResearch square2026

Pulmonary Microvascular Endothelial Antigen Presentation Activates resident CD8

Yuanyun Ao, Kamal Bagale, Sophia Hu, Ahmed Mostafa, Chengjin Ye, Kienan Salvadore, Gregory Gibson, Ricardo Pineda, Jiayue Lu, Rachel Covitz and 11 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Yuanyun AoDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Kamal BagaleDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0001-9330-6540
Sophia HuDepartment of Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-5950-388X
Ahmed MostafaHost-pathogen interactions and Disease Intervention and Prevention programs, Texas Biomedical Research Institute, San Antonio, TX, USA.
Chengjin YeHost-pathogen interactions and Disease Intervention and Prevention programs, Texas Biomedical Research Institute, San Antonio, TX, USA.ORCID https://orcid.org/0000-0002-1934-9494
Kienan SalvadoreDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0009-0003-4459-2853
Gregory GibsonCenter for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA, USA.
Ricardo PinedaDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Jiayue LuDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0009-0008-6811-684X
Rachel CovitzDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Dejuanna ChanDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Ryan LangloisDept of Microbiology & Immunology, University of Minnesota, Minneapolis, MN, USA.
James C ZimringDepartment of Pathology, University of Virginia, Charlottesville, VA, USA.
Paul DuprexCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0003-1716-6376
Claudette M St CroixCenter for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA, USA.
John F AlcornDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0001-5997-7711
Jalees RehmanDepartment of Biochemistry and Molecular Genetics, University of Illinois, College of Medicine, Chicago, IL, USA.ORCID https://orcid.org/0000-0002-2787-9292
Melanie KoenigshoffDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Luis Martinez-SobridoHost-pathogen interactions and Disease Intervention and Prevention programs, Texas Biomedical Research Institute, San Antonio, TX, USA.ORCID https://orcid.org/0000-0001-7084-0804
Jianhua XingDepartment of Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-3700-8765
Lianghui ZhangDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0003-3037-9173

Funding

The Lung Endothelium as an Instructive Niche for the Innate Immune System during Vascular InjuryP01HL160469 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Jalees Rehman · 2022 to 2026
$14.0M
Practices CoreUC7AI180311 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI William Paul Duprex · 2023 to 2026
$13.2M
Amplification Mechanisms of Lung Endothelial Inflammation During Acute Lung InjuryR01HL152515 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI REHMAN, JALEES · 2021 to 2024
$2.3M
Endothelial antigen presentation to T cells as a pathogenic mechanism in influenza-induced acute lung injury.R01HL157489 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZHANG, LIANGHUI · 2021 to 2025
$2.0M
Pathogenic mechanisms of chronic lung sequelae following respiratory viral infectionR01HL176849 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI John F Alcorn, Lianghui Zhang · 2025 to 2026
$1.5M
Learn Systems Biology Equations From Snapshot Single Cell Genomic DataR01GM148525 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jianhua Xing · 2023 to 2026
$1.3M
Pathogenic Mechanism and Therapeutic Approaches for Exercise Intolerance in Post-Acute Sequelae of COVID-19R01HL176493 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Michael G Risbano, Lianghui Zhang · 2025 to 2026
$1.3M
NHLBI NIH HHS P01 HL160469NHLBI NIH HHS R01 HL152515NHLBI NIH HHS R01 HL157489NHLBI NIH HHS R01 HL176493NHLBI NIH HHS R01 HL176849NIAID NIH HHS UC7 AI180311NIGMS NIH HHS R01 GM148525
6 · The paper itself

Abstract

The remaining unacceptably high mortality of influenza-induced acute respiratory distress syndrome underscores the urgent need to identify key cellular drivers of host responses. Endothelial cells (ECs) are increasingly recognized for their immunomodulatory roles, but whether they function as antigen-presenting cells (APCs) following respiratory viral infection remains unknown. Here, we show that influenza A virus H1N1 restrictively infects pulmonary microvascular ECs (PMVECs) during late-stage acute lung injury, triggering robust MHC class I (MHC-I) upregulation in vitro, in vivo, and in ex vivo human precision-cut lung slices. Infected PMVECs present H1N1 antigens via MHC-I and co-stimulatory CD40 to lung-resident CD8

Identifiers

PMID41542053
PMCPMC12803330

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.