ArticleCureus2025
Concentration-Response Relationships of the Non-enzymatic Scavenging Activity of Ethyl Pyruvate Against Multiple Free Radicals.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Background Pyruvate is a metabolic intermediate of energy metabolism that connects glycolysis and the tricarboxylic acid cycle. It also acts as an antioxidant, although it is unstable in solution. Ethyl pyruvate is a derivative of pyruvate with stability and lipid solubility and has been reported to have antioxidative activity. This study aimed to illustrate the concentration-response relationships of the non-enzymatic scavenging activity of ethyl pyruvate against multiple free radicals in vitro. Methodology Eight kinds of free radicals and singlet oxygen were generated in sample tubes. The direct scavenging activities of ethyl pyruvate against free radicals were evaluated by electron spin resonance spectroscopy using the spin-trapping method. Reaction rate constants were estimated from half-maximal inhibitory concentrations of concentration-response relationships. Results Ethyl pyruvate significantly scavenged the following six species of free radicals in concentration-dependent manners: hydroxyl radical (
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