ArticleCureus2025
Long-Term Management of Brain Metastases From Small-Cell Lung Cancer: A Case Report of a Survivor Treated With Multiple Stereotactic Radiosurgeries.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
There is a paucity of studies specifically addressing the treatment of brain metastases with many courses of stereotactic radiosurgery (SRS) over a long duration (i.e., years) of time. Given the morbidity of whole-brain radiotherapy (WBRT), describing the outcomes of patients treated in this manner is important. We report a case of a 48-year-old man who developed a single brain metastasis eight months after completing concurrent chemoradiotherapy for T2aN2M0, Stage IIIA small-cell lung cancer. Over the next ~13 months, each new brain magnetic resonance imaging (MRI) scan (at less than three-month intervals) revealed two to four new, asymptomatic brain metastases. Thereafter, new lesions appeared every two to three MRI scans for 17 months, after which no new lesions developed. Ultimately, he underwent nine separate SRS courses, treating a total of 21 brain metastases, over the course of two and a half years. He never developed extracranial disease progression and no brain metastases locally recurred after SRS. He developed no symptomatic adverse effects from any SRS treatment. He now remains free of disease, with his last SRS more than one year from his last follow-up imaging. This case highlights that in some patients, brain metastases can be considered a potentially chronic condition manageable with multiple courses of SRS over time, in an effort to delay or prevent the need for WBRT.
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