ArticlePCN reports : psychiatry and clinical neurosciences2026
Differential working memory changes following methylphenidate in medication-naive and medication-experienced adults with ADHD.
Article in PCN reports : psychiatry and clinical neurosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Differential working memory changes following methylphenidate in medication-naive and medication-experienced adults with ADHD.PCN reports : psychiatry and clinical neurosciences · 2026Article
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Authors and funding
9 authors.
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Abstract
Aim: The long-term impact of pharmacological treatment on cognitive function in adults with attention-deficit/hyperactivity disorder (ADHD), particularly whether benefits persist after treatment discontinuation, is not well understood. This study aimed to investigate whether prior medication history is associated with different patterns of cognitive change following methylphenidate (MPH) administration. Methods: Thirty-six adults with ADHD (17 medication-naive, 19 medication-experienced) were assessed on five cognitive tasks, the multitasking test (MTT), reaction time (RTI), rapid visual processing (RVP), stop signal task (SST), and spatial working memory (SWM), from the Cambridge Neuropsychological Test Automated Battery baseline and following a period of clinically stable MPH treatment (Post). We used mixed-design ancovas to test for Time × Medication history interactions. Results: We found a significant interaction in the SWM task (6-box condition; Conclusion: Two groups showed differential trajectories of change in the SWM task. Rather than reflecting a purely pharmacological effect, these patterns may involve a combination of baseline cognitive differences, learned cognitive strategies, and pre-existing individual characteristics. These preliminary findings highlight the importance of considering treatment history in clinical practice and research.
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Registered trials
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