Autism Observation Scale for Infants: Systematic Review and Meta-Analysis in Samples at Increased Likelihood of Autism Spectrum Disorders.

Kyle Reid, Lori-Ann R Sacrey, Lonnie Zwaigenbaum, Jessica A Brian, Isabel M Smith

Abstract readReview

In one paragraph

Review in Review journal of autism and developmental disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kyle ReidAutism Research Centre, Department of Pediatrics, Glenrose Rehabilitation Hospital and University of Alberta, Edmonton, Canada.ORCID 0000-0001-8380-1628

Lori-Ann R SacreyAutism Research Centre, Department of Pediatrics, Glenrose Rehabilitation Hospital and University of Alberta, Edmonton, Canada.

Lonnie ZwaigenbaumAutism Research Centre, Department of Pediatrics, Glenrose Rehabilitation Hospital and University of Alberta, Edmonton, Canada.

Jessica A BrianAutism Research Centre, Department of Pediatrics, Holland Bloorview Research Institute and University of Toronto, Toronto, Canada.

Isabel M SmithAutism Research Centre, Departments of Pediatrics, Psychology, and Neuroscience, IWK Health Centre and Dalhousie University, Halifax, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Autism Observation Scale for Infants (AOSI) is being applied to non infant sibling populations. Assessment of the tool's utility across increased likelihood (IL) populations is therefore needed. A systematic review and meta-analysis was conducted on 17 studies identified from six databases. The AOSI has been used in four IL contexts: infant siblings, infants with Fragile X Syndrome, Tuberous Sclerosis Complex, and Down Syndrome. There were three main findings: (1) five studies report classification data though no consistent approach was used; (2) group differences between IL-ASD, IL non-ASD, and controls started at 12-months; and (3) large effect sizes between IL-ASD and control samples was identified. Utility of the AOSI to identify early signs of ASD in IL populations was demonstrated. Supplementary Information: The online version contains supplementary material available at 10.1007/s40489-023-00417-y.

Indexed as

Autism Observation Scale for InfantsAutism Spectrum DisorderDown SyndromeFragile X SyndromeIncreased LikelihoodInfant SiblingsTuberous Sclerosis Complex

Identifiers

PMID41541843

DOI10.1007/s40489-023-00417-y

PMCPMC12799723

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.