Evidence map›Paper›PMID 41541815›Full record

ArticleInnovation and emerging technologies2025

The organ-on-a-chip mirage: Animal replacement, plastic channels, and plastic claims:

Martin L Yarmush

Abstract read
In one paragraph

Article in Innovation and emerging technologies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Martin L YarmushDepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ, USA, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0003-4986-8444

Funding

Collaborations to Extend the Microphysiology Database for Multiple Organ Models,UH2TR000503 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TAYLOR, D. LANSING, YARMUSH, MARTIN L · 2012 to 2013
$2.3M
NCATS NIH HHS UH2 TR000503
6 · The paper itself

Abstract

Organ-on-a-chip platforms have been widely promoted as imminent replacements for animal research, a theme prominently featured in

Indexed as

Drug-Induced Liver Injury (DILI)New Approach Methodologies (NAMs)Organ-on-a-ChipPredictive ToxicologyTranslational Medicine

Identifiers

PMID41541815
PMCPMC12803743

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.