ArticleJournal of multimorbidity and comorbidity
Maternal multimorbidity and chronic conditions as predictors of preterm birth: A matched case-control study in Cyprus.
Article in Journal of multimorbidity and comorbidity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Preterm birth (PTB) is a leading global cause of neonatal morbidity and mortality. While individual maternal chronic conditions are established risk factors, the role of maternal multimorbidity remains underexplored. This study aimed to examine the association between maternal multimorbidity and PTB, and to identify chronic conditions associated with the occurrence and severity of PTB. Methods: A retrospective matched case-control study was conducted at Archbishop Makarios III Hospital in Nicosia, Cyprus. The sample included 978 singleton live births, consisting of 489 preterm cases (<37 weeks) matched 1:1 with 489 term controls (≥37 weeks) by maternal age and country of origin. Data were extracted from patient's medical records. Multimorbidity was defined as the presence of two or more chronic conditions. Conditional logistic regression assessed associations with PTB, and binary logistic regression examined predictors of extreme/very PTB (<32 weeks) versus moderate/late PTB (32 to <37 weeks). Results: Maternal multimorbidity was associated with increased odds of PTB (aOR = 1.80; 95% CI: 1.16-2.79; p=0.009). Hypertension (aOR=4.26; 95% CI: 1.84-9.86), kidney disease (aOR=3.67; 95% CI: 1.01-13.30), thrombophilia (aOR=3.53; 95% CI: 1.14-10.88), thyroid disorders (aOR = 1.77; 95% CI: 1.05-2.98), and allergies (aOR=1.82; 95% CI: 1.12-2.99) were independently associated with PTB. Diabetes was inversely associated with extreme PTB (aOR=0.19; 95% CI: 0.10-0.92). Conclusions: Maternal multimorbidity and several chronic conditions are significant and independent predictors of PTB. These findings underscore the importance of comprehensive antenatal screening and integrated care for women with multiple health conditions. Tailored risk assessment strategies may help reduce the burden of PTB, particularly in populations with rising rates of chronic disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.