Evidence map›Paper›PMID 41541673›Full record

ArticleiScience2026

Extreme temperature and humidity exposure elevates acute intracerebral hemorrhage risk.

Shengli Hu, Hao Peng, Yong Xu, Jun Zhao, Zhizhen Wei, Anwei Zhang, Can Huang, Yuting Si, Yingying Tang, Kuanming Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shengli HuDepartment of Cerebrovascular Disease Diagnosis and Treatment Center, Hubei Provincial Clinical Research Center of Central Nervous System Repair and Functional Reconstruction, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China.
Hao PengDepartment of Cerebrovascular Disease Diagnosis and Treatment Center, Hubei Provincial Clinical Research Center of Central Nervous System Repair and Functional Reconstruction, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China.
Yong XuDepartment of Neurorehabilitation Centers, Hubei Provincial Clinical Research Center of Central Nervous System Repair and Functional Reconstruction, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China.
Jun ZhaoSchool of Public Health, Hubei University of Medicine, Shiyan 442000, Hubei, China.
Zhizhen WeiDepartment of Cerebrovascular Disease Diagnosis and Treatment Center, Hubei Provincial Clinical Research Center of Central Nervous System Repair and Functional Reconstruction, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China.
Anwei ZhangDepartment of Cerebrovascular Disease Diagnosis and Treatment Center, Hubei Provincial Clinical Research Center of Central Nervous System Repair and Functional Reconstruction, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China.
Can HuangDepartment of Cerebrovascular Disease Diagnosis and Treatment Center, Hubei Provincial Clinical Research Center of Central Nervous System Repair and Functional Reconstruction, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China.
Yuting SiDepartment of Cerebrovascular Disease Diagnosis and Treatment Center, Hubei Provincial Clinical Research Center of Central Nervous System Repair and Functional Reconstruction, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China.
Yingying TangDepartment of Cerebrovascular Disease Diagnosis and Treatment Center, Hubei Provincial Clinical Research Center of Central Nervous System Repair and Functional Reconstruction, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China.
Kuanming HuangDepartment of Cerebrovascular Disease Diagnosis and Treatment Center, Hubei Provincial Clinical Research Center of Central Nervous System Repair and Functional Reconstruction, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study examines the association between extreme temperature, relative humidity, and acute intracerebral hemorrhage (ICH) risk using a time-stratified case-crossover design. Data from 2,284 ICH patients in the northwestern region of Hubei Province, China, were analyzed, focusing on extreme environmental conditions. Extreme low temperatures significantly increased ICH risk, peaking around 18 h post exposure, while low humidity was associated with a risk peak at 7 h post exposure. Sensitivity analyses confirmed the robustness of these findings, with extended lag periods showing sustained risk but decreasing magnitude over time. Subgroup analyses revealed higher vulnerability among lobar hemorrhage patients and older adults. These findings highlight the importance of environmental factors, particularly cold and low humidity, in ICH risk and stress the need for targeted public health interventions for vulnerable populations during extreme weather events.

Indexed as

climatologyneuroscience

Identifiers

PMID41541673
PMCPMC12799769

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.