Evidence map›Paper›PMID 41541643›Full record

ArticleTherapeutic advances in gastroenterology2026

Endoscopic ultrasonography-guided cyanoacrylate injection versus endoscopic cyanoacrylate injection for treating isolated gastric varices type 1 bleeding with spontaneous shunts: a randomized controlled trial.

Jing Li, Yaxian Kuai, Xuecan Mei, Zhihong Wang, Zhuang Zeng, Yingying He, Derun Kong

Abstract read
In one paragraph

Article in Therapeutic advances in gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. EUS-guidedEndoscopic ultrasound
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jing LiDepartment of Gastroenterology, Third People's Hospital of Bengbu, Anhui, China.ORCID https://orcid.org/0009-0000-5950-1422
Yaxian KuaiDepartment of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Anhui, China.
Xuecan MeiDepartment of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Anhui, China.
Zhihong WangDepartment of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Anhui, China.
Zhuang ZengDepartment of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Anhui, China.
Yingying HeDepartment of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Anhui, China.
Derun KongDepartment of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei, Anhui 230000, China.ORCID https://orcid.org/0000-0002-3273-5760

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Isolated gastric varices type 1 (IGV1) with spontaneous shunts carry a high risk of bleeding and ectopic embolization following cyanoacrylate injection. Objectives: This study aimed to compare the efficacy and safety of endoscopic ultrasonography-guided cyanoacrylate injection (EUS-CYA) versus direct endoscopic injection of cyanoacrylate (DEI-CYA) in patients with IGV1 and spontaneous shunts. Design: A prospective randomized controlled trial (RCT). Methods: This prospective RCT enrolled patients with cirrhosis complicated by IGV1 and spontaneous portosystemic shunts. Eligible patients were randomly assigned to either the EUS-CYA group or the DEI-CYA group. The primary outcome was the rebleeding rate, while the secondary outcomes included technical success rate, gastric varices occlusion rate, cumulative non-bleeding rate, mortality rate, and incidence of ectopic embolization. Results: A total of 96 patients were randomized to either the EUS-CYA ( Conclusion: EUS-CYA demonstrates a higher gastric varices occlusion rate and a lower rebleeding rate for IGV1 with spontaneous shunts compared to DEI-CYA. Trial registration: Chinese Clinical Trial Registry, ChiCTR2200058888.

Indexed as

cyanoacrylate injectionendoscopic ultrasoundgastric varicesspontaneous shunts

Identifiers

PMID41541643
PMCPMC12799999

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.