Evidence map›Paper›PMID 41541628›Full record

ArticleJournal of nutritional science2026

The predictive factors of hypozincemia in patients with chronic liver disease.

Shoji Ando, Atsumasa Komori, Hiroshi Yatsuhashi, Seigo Abiru, Yuri Yotsumoto

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Article in Journal of nutritional science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Shoji AndoDepartment of Nutritional Management, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan.ORCID https://orcid.org/0009-0005-1580-2713
Atsumasa KomoriDepartment of Treatment for Intractable Disease, Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan.
Hiroshi YatsuhashiClinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan.
Seigo AbiruClinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan.
Yuri YotsumotoDepartment of Nutritional Management, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with chronic liver disease (CLD) often experience hypozincemia. The clinical factors associated with hypozincemia have not been established. We investigated clinical factors that may be useful to predict hypozincemia in patients with CLD. The serum zinc levels CLD patients were measured; Study 1 investigated the predictive factors of hypozincemia, and Study 2 was performed to validate the factors identified in Study 1. Study 1 included 197 participants, of whom 28 and 106 had serum zinc levels <60 µg/dL and <80 µg/dL, respectively. A multivariate analysis revealed that serum zinc levels <60 µg/dL or <80 µg/dL were associated with the albumin-bilirubin (ALBI) score and serum albumin level. A receiver operating characteristic curve analysis revealed that the ALBI score ≥ -1.83 and the serum albumin level ≤3.3 g/dL were the cut-off values for a serum zinc level <60 µg/dL, whereas the ALBI score ≥ -2.44 and the serum albumin level ≤3.6 g/dL were the cut-off values for a serum zinc level <80 µg/dL. In Study 2 (

Indexed as

Liver DiseasesZincAdultAgedBilirubinChronic DiseaseFemaleHumansMaleMiddle AgedMultivariate AnalysisPredictive Value of TestsROC CurveSerum AlbuminBilirubinSerum AlbuminZincALBI, albumin–bilirubinALBI scoreAlbuminALT, alanine aminotransferaseAST, aspartate aminotransferaseBMI, body mass indexChronic liver diseaseCLD, chronic liver diseaseCONUT, controlling nutritional statusCRP, C-reactive proteinDiureticFIB, fibrosisHCC, hepatocellular carcinomaHOMA-IR, the homeostasis model assessment of insulin resistanceMASLD, metabolic dysfunction-associated steatotic liver diseaseMDA, malondialdehydeNPV, negative predictive valuePPV, positive predictive valueRCTs, randomised controlled trialsROC, receiver operating characteristicSOD1, superoxide dismutase 1Zincγ-GTP, gamma-glutamyl transpeptidase

Identifiers

PMID41541628
PMCPMC12800535

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.