Evidence map›Paper›PMID 41541570›Full record

ArticlePhysics and imaging in radiation oncology2026

Accuracy of reirradiation dose constraints for the mandible and carotids.

Sara Bornedal, Jeehong Lee, Tim Melhus, Anna Embring, Eva Onjukka

Abstract read
In one paragraph

Article in Physics and imaging in radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sara BornedalDepartment of Nuclear Medicine and Medical Physics, Karolinska University Hospital, Stockholm, Sweden.
Jeehong LeeDepartment of Nuclear Medicine and Medical Physics, Karolinska University Hospital, Stockholm, Sweden.
Tim MelhusDepartment of Nuclear Medicine and Medical Physics, Karolinska University Hospital, Stockholm, Sweden.
Anna EmbringDepartment of Radiotherapy, Karolinska University Hospital, Stockholm, Sweden.
Eva OnjukkaDepartment of Nuclear Medicine and Medical Physics, Karolinska University Hospital, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

When reirradiation dose constraints are derived using accumulated dose, the underlying image registrations contribute to the uncertainty. We performed a structure-based evaluation of deformable image registrations, to estimate the uncertainty in previously published dose constraints related to carotid blowout and osteoradionecrosis after head and neck reirradiation. With the workflow of the current analysis, the uncertainty was small in the majority of the cases (<4 Gy in accumulated equivalent dose in 2-Gy fractions), but with substantial outliers resulting from anatomical alterations. Our previously suggested dose constraints appear to be reliable with regard to the underlying image registrations.

Indexed as

Accumulated doseDeformable image registrationDose constraintsHead and neck cancerReirradiation

Identifiers

PMID41541570
PMCPMC12799775

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.