Evidence map›Paper›PMID 41541552›Full record

ArticleJID innovations : skin science from molecules to population health2026

Chromatin Accessibility Profiling of Keratinocytes from Clinically Healed Psoriatic Skin Reveals Epigenetic Alterations.

Sayaka Shibata, Kentaro Awaji, Asumi Koyama, Haruka Taira, Toyoki Yamamoto, Lixin Li, Yukiko Ito, Shunsuke Miura, Takashi Yamashita, Takuya Miyagawa and 1 more

Abstract read
In one paragraph

Article in JID innovations : skin science from molecules to population health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sayaka ShibataDepartment of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kentaro AwajiDepartment of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Asumi KoyamaDepartment of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Haruka TairaDepartment of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Toyoki YamamotoDepartment of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Lixin LiDepartment of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yukiko ItoDepartment of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Shunsuke MiuraDepartment of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Takashi YamashitaDepartment of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Takuya MiyagawaDepartment of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Shinichi SatoDepartment of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriasis is a chronic inflammatory skin disease with recurrence that often reappears at previously affected sites, suggesting an epigenetic imprint in healed skin. However, the chromatin landscape of clinically healed psoriatic keratinocytes remains uncharacterized. We performed Assay for Transposase-Accessible Chromatin using sequencing on epidermal keratinocytes isolated from psoriasis-affected, clinically healed, and control skin samples. Compared with those of healthy skin, psoriasis-affected keratinocytes exhibited widespread alterations in chromatin accessibility. Although most of these disease-associated changes resolved after clinical remission, 152 peaks remained differentially accessible, particularly at NF-κB-associated immune-regulatory loci, including

Indexed as

ATAC-seqEpigeneticsKeratinocytesPsoriasis

Identifiers

PMID41541552
PMCPMC12800420

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.