Evidence map›Paper›PMID 41541499›Full record

ArticleJVS-vascular science2026

Role of adipocyte angiotensinogen or angiotensin type 1a receptors in the development of diet-induced atherosclerosis or angiotensin II-induced abdominal aortic aneurysms.

Yasir AlSiraj, Kelly Putnam, Seth I Brunner, Victoria L English, Charles M Ensor, Lisa A Cassis

Abstract read
In one paragraph

Article in JVS-vascular science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yasir AlSirajDepartment of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY.
Kelly PutnamDepartment of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY.
Seth I BrunnerDepartment of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY.
Victoria L EnglishDepartment of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY.
Charles M EnsorDepartment of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY.
Lisa A CassisDepartment of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY.

Funding

Pilot Projects ProgramP30GM127211 · NIGMS · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2018 to 2022
$5.7M
Angiotensin: A Link Between Obesity and HypertensionR01HL073085 · NHLBI · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2003 to 2017
$5.0M
The serotonergic system in periaortic fat regulates regional aortopathy developmentR01HL168633 · NHLBI · UNIVERSITY OF KENTUCKY · PI Lisa A Cassis · 2023 to 2026
$2.5M
NHLBI NIH HHS R01 HL073085NHLBI NIH HHS R01 HL168633NIGMS NIH HHS P30 GM127211
6 · The paper itself

Abstract

Objective: Adipocytes express renin-angiotensin system (RAS) components, including angiotensinogen ( Methods: For atherosclerosis, adipocyte Results: There was no effect of adipocyte Conclusions: Adipocyte Clinical Relevance: These studies address the role of components of the renin-angiotensin system (RAS), namely, angiotensinogen and angiotensin type 1a receptors, within adipocytes on experimental disease models of atherosclerosis and abdominal aortic aneurysms. Adipocytes express these RAS components and dysfunctional adipose tissue in humans has been linked both to atherosclerosis and abdominal aortic aneurysm severity. Our findings do not support a major role for these adipocyte RAS components in either disease model. Thus, although drugs targeting the RAS may be beneficial in the treatment of these disorders, they are likely not more effective in the obese population experiencing either of these disorders.

Indexed as

Abdominal aortic aneurysmAdipocyteAngiotensinogenAngiotensin type 1 receptorAtherosclerosis

Identifiers

PMID41541499
PMCPMC12800483

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.