Evidence map›Paper›PMID 41541497›Full record

ArticleRespirology case reports2026

Antiphospholipid Syndrome Mimicking Acute Exacerbation of Interstitial Pneumonia: A Case Report and Literature Review.

Saki Ishii, Hiroki Wakabayashi, Kazutoshi Isobe, Ryogo Ohashi, Kensuke Namba, Misa Iwayanagi, Hiromasa Sakurai, Daiki Sakai, Kenta Takashima, Yu Murakami and 2 more

Abstract read
In one paragraph

Article in Respirology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Saki IshiiDivision of Respiratory Medicine, Department of Internal Medicine Toho University Sakura Medical Center Chiba Japan.ORCID https://orcid.org/0009-0000-5620-4385
Hiroki WakabayashiDivision of Respiratory Medicine, Department of Internal Medicine Toho University Sakura Medical Center Chiba Japan.ORCID https://orcid.org/0000-0002-8705-441X
Kazutoshi IsobeDivision of Respiratory Medicine, Department of Internal Medicine Toho University Sakura Medical Center Chiba Japan.ORCID https://orcid.org/0000-0002-9995-2217
Ryogo OhashiDivision of Respiratory Medicine, Department of Internal Medicine Toho University Sakura Medical Center Chiba Japan.
Kensuke NambaDivision of Respiratory Medicine, Department of Internal Medicine Toho University Sakura Medical Center Chiba Japan.ORCID https://orcid.org/0009-0000-1775-347X
Misa IwayanagiDivision of Respiratory Medicine, Department of Internal Medicine Toho University Sakura Medical Center Chiba Japan.
Hiromasa SakuraiDivision of Respiratory Medicine, Department of Internal Medicine Toho University Sakura Medical Center Chiba Japan.
Daiki SakaiDivision of Respiratory Medicine, Department of Internal Medicine Toho University Sakura Medical Center Chiba Japan.
Kenta TakashimaDivision of Respiratory Medicine, Department of Internal Medicine Toho University Sakura Medical Center Chiba Japan.
Yu MurakamiDivision of Respiratory Medicine, Department of Internal Medicine Toho University Sakura Medical Center Chiba Japan.
Kaichi KanekoDivision of Respiratory Medicine, Department of Internal Medicine Toho University Sakura Medical Center Chiba Japan.
Yasuo MatsuzawaDivision of Respiratory Medicine, Department of Internal Medicine Toho University Sakura Medical Center Chiba Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute exacerbation of interstitial pneumonia (IP-AE) is a type of severe respiratory failure that occurs in patients with chronic interstitial pneumonia. Herein, we report a case of multiple pulmonary thrombi caused by antiphospholipid antibody syndrome (APS), which required differentiation from IP-AE in a patient with chronic interstitial pneumonia. A 77-year-old male patient presented with acute respiratory failure and bilateral ground-glass opacities on chest computed tomography (CT), which initially indicated IP-AE. However, the contrast-enhanced CT scan revealed multiple pulmonary thrombi, and the laboratory examination showed positivity for antiphospholipid antibodies. The patient was diagnosed with APS and was successfully treated with anticoagulant therapy and systemic corticosteroids. The pulmonary manifestations of APS may mimic those of IP-AE and may be under-recognised. Thus, APS should be considered in the differential diagnosis of acute respiratory deterioration in patients with interstitial pneumonia.

Indexed as

acute exacerbation of interstitial pneumoniaanticoagulation therapyantiphospholipid syndromeautoimmune diseasecatastrophic antiphospholipid syndrome

Identifiers

PMID41541497
PMCPMC12800897

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.