Evidence map›Paper›PMID 41541269›Full record

ArticleMolecular therapy. Nucleic acids2026

Ribofuranose-based GalNAc-conjugated siRNA enhances the liver-targeted delivery and elicits robust RNAi-mediated gene silencing.

Ze-Ao Huang, Zhen-Min Li, Jie Wang, Guang-Shen Ji, Zhong-Cai Gao, Ai-Fu Chen, Zhi-Kang Tian, Fei Yu, Geng-Shen Song

Abstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ze-Ao HuangBeijing Youcare Kechuang Pharmaceutical Technology Co., Ltd., Kechuang 7th Street, BDA, Beijing 100176, China.
Zhen-Min LiHangzhou Tianlong Pharmaceutical Co., Ltd., Yinhai Science and Technology Innovation Center, Room 701, Building 3, Xiasha Subdistrict, Qiantang District, Hangzhou, Zhejiang 310020, China.
Jie WangHangzhou Tianlong Pharmaceutical Co., Ltd., Yinhai Science and Technology Innovation Center, Room 701, Building 3, Xiasha Subdistrict, Qiantang District, Hangzhou, Zhejiang 310020, China.
Guang-Shen JiBeijing Youcare Kechuang Pharmaceutical Technology Co., Ltd., Kechuang 7th Street, BDA, Beijing 100176, China.
Zhong-Cai GaoBeijing Youcare Kechuang Pharmaceutical Technology Co., Ltd., Kechuang 7th Street, BDA, Beijing 100176, China.
Ai-Fu ChenBeijing Youcare Kechuang Pharmaceutical Technology Co., Ltd., Kechuang 7th Street, BDA, Beijing 100176, China.
Zhi-Kang TianBeijing Youcare Kechuang Pharmaceutical Technology Co., Ltd., Kechuang 7th Street, BDA, Beijing 100176, China.
Fei YuBeijing Youcare Kechuang Pharmaceutical Technology Co., Ltd., Kechuang 7th Street, BDA, Beijing 100176, China.
Geng-Shen SongBeijing Youcare Kechuang Pharmaceutical Technology Co., Ltd., Kechuang 7th Street, BDA, Beijing 100176, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The

Indexed as

deoxyribofuranose ringGalNAc-siRNA conjugatesliver-targeted deliveryMT: Delivery StrategiesN-acetylgalactosaminePCSK9ribofuranose ringtetrahydropyrrole ring

Identifiers

PMID41541269
PMCPMC12800395

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.