ArticleFrontiers in stroke2023
Advancing stroke genetics in Hawai'i and the Pacific Islands.
Article in Frontiers in stroke, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
6 authors.
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Abstract
Stroke, the second leading cause of death worldwide, has partially heritable risk. Genome-wide association studies (GWAS) of stroke continue to identify increasing genetic risk loci. These discoveries point to novel disease mechanisms and causal risk factors, and herald genetics-based precision medicine strategies. In Hawai'i, people of Indigenous communities who identify as Native Hawaiian or Pacific Islanders present with stroke at younger ages and suffer dramatically higher stroke mortality rates compared with other regional populations. This disparity is compounded by relative ancestral underrepresentation in stroke genetics research and, by extension, exclusion from cutting-edge medical opportunities based on genetic discovery. In this article, we discuss the issues contributing to the scientific biases experienced by Indigenous populations in the Pacific Islands, as well as community-based efforts now underway to address them.
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