ArticleSeminars in arthroplasty2023
Effect of Supplemental Testosterone Use on Shoulder Arthroplasty Infection Rates.
Article in Seminars in arthroplasty, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Pre-operative injectable testosterone therapy is associated with increased five-year revision risk after total shoulder arthroplasty: a TriNetX database analysis.Journal of shoulder and elbow arthroplasty · 2026Article
- Testosterone Replacement Therapy in Posterior Lumbar Fusion Patients: A Propensity Score-Matched Analysis of Long-Term Outcomes.Global spine journal · 2026Article
- Risk of complications after total hip arthroplasty in patients on testosterone replacement therapy.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Article
- Prescription testosterone is associated with increased risk of infection-related and all-cause reoperations after primary total shoulder arthroplasty in male patients.JSES international · 2026Article
- Perioperative testosterone therapy linked to higher 5-year risk of periprosthetic joint infection without increased 90-day major complications or revision rates in total shoulder arthroplasty.Shoulder & elbow · 2026Article
- Association between hormone replacement therapy and clinical outcomes in women with rotator cuff tears.Archives of ISPRM · 2026Article
- Association of Testosterone Supplementation with the Risk of Infection following Primary Total Hip Arthroplasty.Hip & pelvis · 2025Article
- Increasing use of reverse total shoulder arthroplasty in younger adults despite higher complication rates.JSES international · 2025Article
- Testosterone Replacement Therapy Is Not Associated with Greater Revision Rates in Reverse Total Shoulder Arthroplasty.Journal of clinical medicine · 2025Article
- Perioperative Management, Complications, and Outcomes of Shoulder Arthroplasty in Patients with Diabetes Mellitus.JBJS reviews · 2025Review
- The shoulder microbiome: a systematic review and meta analysis.JSES reviews, reports, and techniques · 2024Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Background: Supplemental testosterone use among patients undergoing shoulder arthroplasty can increase the Methods: The PearlDiver database was queried to identify a cohort of patients who underwent shoulder arthroplasty (hemiarthroplasty, anatomic or reverse total shoulder arthroplasty) with minimum 2-year follow-up. Current Procedural Terminology (CPT) and International Classification of Diseases (ICD) codes were used to compare the demographics and comorbidities of patients with (n = 2,285) and without testosterone use (n = 41,712). Patients with testosterone use were further stratified by the duration between last testosterone use and surgery. Prosthetic joint infection rates were compared between those with and without testosterone use. Results: The overall prevalence of testosterone use was 3.4%. Patients who used testosterone within 6-months prior to shoulder arthroplasty had a significantly higher rate of prosthetic joint infection at 3.4% compared to those without use at 2.4% [odds ratio (OR) = 1.44 (95% confidence interval (CI): 1.03 - 2.01, p = 0.042]. However, patients who used testosterone between 6- and 12-months before surgery did not have a significantly higher rate of infection. On multivariate analysis, only younger age [OR = 0.98 (95% CI: 0.97 - 0.99), p < 0.001] and diabetes [OR = 1.26 (95% CI: 1.10 - 1.44), p < 0.001] were independent risk factors for development of an infection. Conclusion: Testosterone use within 6-months of shoulder arthroplasty may be associated with higher rates of prosthesis joint infection. However, patients who were taking testosterone but stopped before surgery did not have a higher rate of infection compared to those who never used the medication. Surgeons should actively screen patients for testosterone use. A referral to the patient's endocrinologist to discuss the risks and benefits of testosterone cessation prior to shoulder arthroplasty may also be warranted. Level of Evidence: Level III; Retrospective Cohort Study using Large Database.
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