ArticleOsteoarthritis and cartilage open2026
Acellular placental extract outcomes in post-traumatic osteoarthritis model.
Article in Osteoarthritis and cartilage open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Evaluate the effect of human placental extract (HPE) on healthy and osteoarthritic articular cartilage. Method: Post-traumatic osteoarthritis (PTOA) rodent model was utilized to assess functional and histologic outcomes of HPE administration at 1, 2 and 3 months. Matrix metalloproteinase (MMP), glycosaminoglycan (GAG) content were assessed via human and porcine cartilage explants exposed to either HPE or saline cohorts. Results: Improved gait function of PTOA-induced rodents treated with HPE in 5 measured parameters, persisting to the 3-month time point against the saline control. No significant difference in medial or lateral joint space was found on MicroCT evaluation after normalizing results to the contralateral uninjured limb. OARSI scores of the medial compartment of PTOA rodents at 3-months showed preservation of cartilage in the HPE-treated cohort with a score of 1.8 for HPE versus 9.17 for saline ( Conclusions: HPE may be a promising treatment for OA by inhibiting the metabolic process of ECM breakdown and preserving the structural integrity of the knee joint in comparison to saline control.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.