Evidence map›Paper›PMID 41540968›Full record

ArticleJMIR research protocols2025

Examining the Relationship Between Alcohol Use Disorder and Glaucoma: Protocol for a Scoping Review.

Fatima Elghazali, Alexandria Hughes, Tracy Shields, Jennifer J Barb, Gwenyth R Wallen

Abstract read
In one paragraph

Article in JMIR research protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fatima ElghazaliTranslational Biobehavioral and Health Promotion Branch, Clinical Center, National Institutes of Health, 10 Center Dr, Bethesda, MD, 20892, United States, 1 301-435-9232.ORCID 0009-0009-3171-4659
Alexandria HughesTranslational Biobehavioral and Health Promotion Branch, Clinical Center, National Institutes of Health, 10 Center Dr, Bethesda, MD, 20892, United States, 1 301-435-9232.ORCID 0000-0003-3922-7045
Tracy ShieldsNIH Research Library, National Institutes of Health, Bethesda, MD, United States.ORCID 0000-0001-5670-7388
Jennifer J BarbTranslational Biobehavioral and Health Promotion Branch, Clinical Center, National Institutes of Health, 10 Center Dr, Bethesda, MD, 20892, United States, 1 301-435-9232.ORCID 0000-0003-3022-0154
Gwenyth R WallenTranslational Biobehavioral and Health Promotion Branch, Clinical Center, National Institutes of Health, 10 Center Dr, Bethesda, MD, 20892, United States, 1 301-435-9232.ORCID 0000-0001-7134-1636

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Alcohol use disorder (AUD) is a condition characterized by uncontrollable alcohol use despite negative social, occupational, or health consequences. AUD affects major organ systems in the body, including the eyes, in different ways. Alcohol seems to have dose-dependent effects on intraocular pressure (IOP), with some quantities lowering IOP and promoting blood flow to the optic nerve head, whereas higher quantities are linked to cardiovascular disorders and systemic physiological changes affecting glaucoma development. Current research shows mixed findings on the correlation between alcohol consumption and glaucoma, and little has been investigated in the AUD population. This paper outlines a protocol for a scoping review that aims to characterize the literature on the connection between AUD and its related conditions, such as alcohol dependence and alcohol misuse, and glaucoma and its associated symptoms, including increased IOP, optic nerve damage, and vision loss. Objective: The overarching goal of this scoping review is to synthesize an extensive overview of the current literature surrounding AUD or alcohol consumption and glaucoma. We aim to (1) map the existing literature on alcohol and glaucoma; (2) identify how alcohol consumption is associated with glaucoma; and (3) synthesize evidence concerning the association between AUD or alcohol consumption, including drinking frequency, quantity, and type, and glaucoma. Methods: A biomedical librarian will conduct a systematic search of PubMed and MEDLINE, Embase, Web of Science, and CENTRAL. A 2-step process will be used to screen the results, using Covidence as the screening software. All unique records retrieved from the databases and those identified through supplemental searches will be screened by 2 reviewers independently using the eligibility criteria. This will be followed by data charting. This evidence synthesis will summarize findings in narrative and tabular formats. Results: This scoping review was started in Covidence in November 2024 and is currently funded by the National Institutes of Health Intramural Research Program. The projected end date for data collection and submission is between November 2025 and January 2026. Conclusions: This scoping review aims to clarify the mixed findings on the association between AUD or alcohol consumption and glaucoma. The findings will guide future research in this area.

Indexed as

AlcoholismGlaucomaAlcohol DrinkingHumansIntraocular PressureResearch DesignScoping Reviews as Topicalcohol abusealcohol consumptionalcohol use disorderAUDglaucoma

Identifiers

PMID41540968
PMCPMC12809109

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.