Evidence map›Paper›PMID 41540757›Full record

Trial reportBrain and behavior2026

Rehabilitation-Cognition Integrated Care Program for Elderly With Lower Limb Fractures and Cognitive Impairment: Development and Efficacy.

Qinfen Chen, Xiaozhen Ding, Yongmin Wei, Jiahao Wang, Mingping Zhou, Yuanyuan Chen, Yanlin Chen

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qinfen ChenDepartment of Traumatology and Orthopedics, The First Affiliated Hospital of Lishui University, Lishui, Zhejiang, China.
Xiaozhen DingDepartment of Traumatology and Orthopedics, The First Affiliated Hospital of Lishui University, Lishui, Zhejiang, China.
Yongmin WeiDepartment of Traumatology and Orthopedics, The First Affiliated Hospital of Lishui University, Lishui, Zhejiang, China.
Jiahao WangDepartment of Rehabilitation, The First Affiliated Hospital of Lishui University, Lishui, Zhejiang, China.
Mingping ZhouDepartment of Traumatology and Orthopedics, The First Affiliated Hospital of Lishui University, Lishui, Zhejiang, China.
Yuanyuan ChenDepartment of Nursing, The First Affiliated Hospital of Lishui University, Lishui, Zhejiang, China.
Yanlin ChenDepartment of Traumatology and Orthopedics, The First Affiliated Hospital of Lishui University, Lishui, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo develop and assess the efficacy of a rehabilitation-cognition integrated care (RCIC) program for elderly patients with lower limb fractures and mild-to-moderate cognitive impairment.

methodsA total of 128 eligible patients during January 2023 to December 2024 were randomly allocated to conventional (n = 64) or integrated care group (n = 64). Both groups received 12 weeks of intervention. Outcomes, including Fugl-Meyer Assessment (FMA), Berg Balance Scale (BBS), Montreal Cognitive Assessment (MoCA), Functional Independence Measure (FIM), and Hospital Anxiety and Depression Scale (HADS) scores, were compared. Serum neurotrophic and neuroinflammatory markers were analyzed pre- and post-intervention. Complications, fall recurrence rates, and nursing satisfaction were recorded.

resultsPost-intervention, both groups showed improved FMA, BBS, and FIM scores, with significantly greater improvement in the integrated care group (p < 0.05). HADS-Anxiety (HADS-A) and HADS-Depression (HADS-D) scores decreased significantly more in the integrated care group (p < 0.05). The integrated care group demonstrated higher MoCA scores versus both its own baseline and the conventional care group post-intervention (p < 0.05). Serum BDNF and GDNF levels increased significantly in the integrated care group compared to both time-matched controls and its baseline (p < 0.05), while S100-β and IL-6 levels decreased significantly (p < 0.05). The integrated care group had lower overall complication rates (p < 0.05), comparable fall recurrence (p > 0.05), and higher nursing satisfaction (p < 0.05).

conclusionThe RCIC program significantly enhances motor function, balance, cognition, and psychological status while reducing complications and improving satisfaction in elderly fracture patients with cognitive impairment.

Indexed as

Cognitive DysfunctionFractures, BoneAgedAged, 80 and overCognitionFemaleHumansLower ExtremityMaleTreatment Outcomecognitive functionelderly patientsfunctional recoverylower limb fracturesmild‐to‐moderate cognitive impairmentrehabilitation–cognition integrated care

Identifiers

PMID41540757
PMCPMC12808919

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.