ArticleAngewandte Chemie (International ed. in English)2026
Experimental Isolation of Single Impact, Cumulative Energy, Aging, and Liquid-Assisted Grinding Effects in Mechanochemical Reactions.
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Machine learning-assisted development of a fast Mechanochemical Johnson-Corey-Chaykovsky reaction.Nature communications · 2026Article
- Mechanochemically assembled organometallic complexes: a mechanistic study.Chemical science · 2026Article
- Scalable mechanochemical synthesis of a cyclic dehydroalanine peptide.Organic & biomolecular chemistry · 2026Article
- The role of ball mass, surface, and contact dynamics in mechanochemical reactions.RSC mechanochemistry · 2026Article
- Motion matters: the role of milling ball trajectories in mechanochemical reactions.RSC mechanochemistry · 2026Article
- Experimental Isolation of Single Impact, Cumulative Energy, Aging, and Liquid-Assisted Grinding Effects in Mechanochemical Reactions.Angewandte Chemie (International ed. in English) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Mechanochemical reactivity arises from a complex interplay between single impact energy, cumulative energy input, and secondary effects such as aging or liquid-assisted grinding (LAG). Here, we experimentally isolate these factors across two fundamentally different all-solid reactions-the Finkelstein halogen exchange and the Wittig olefination-using a standardized single-ball mixer mill setup. Systematic variation of milling parameters revealed that both reactions are impact-driven but differ in how mechanical energy translates into chemical conversion. The halogen exchange exhibited pronounced aging, where the transformation continues after mechanical activation, highlighting the contribution of post-impact reactivity. In contrast, the Wittig olefination, free of such secondary effects, showed an almost ideal linear correlation between yield and cumulative energy (E
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.