Evidence map›Paper›PMID 41540573›Full record

ReviewBJPsych open2026

The prevalence of autism spectrum traits and autism spectrum disorders in children and adolescents with obsessive compulsive disorder: systematic review and meta-analysis.

Claire Tiley, Paraskevi Lampropoulou, Myrto Samara, Marinos Kyriakopoulos

Abstract readReview
In one paragraph

Review in BJPsych open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Claire TileyChild and Adolescent Mental Heath Services, https://ror.org/015803449South London and Maudsley NHS Foundation Trust, London, UK.ORCID https://orcid.org/0000-0003-1564-9470
Paraskevi LampropoulouDepartment of Psychiatry, Faculty of Medicine, University of Thessaly, Larissa, Greece.ORCID https://orcid.org/0000-0001-9145-5307
Myrto SamaraDepartment of Psychiatry, Faculty of Medicine, University of Thessaly, Larissa, Greece.ORCID https://orcid.org/0000-0002-6943-5091
Marinos KyriakopoulosChild and Adolescent Mental Heath Services, https://ror.org/015803449South London and Maudsley NHS Foundation Trust, London, UK.ORCID https://orcid.org/0000-0002-4594-2646

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAutism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) may coexist in children and adolescents and present with several overlapping features.

aimsWe aimed to assess the prevalence of ASD traits and diagnosis in children and adolescents with OCD, explore the correlation between OCD severity and ASD traits/diagnosis, and examine the impact of ASD traits/diagnosis on global functioning in this population.

methodElectronic searches were carried out on Pubmed, Embase and PsycINFO, using selected keywords and specified inclusion and exclusion criteria. Meta-analysis was performed with R Version 4.3.1.

resultsOf 1410 studies initially identified, 29 reported on the prevalence of ASD traits or diagnosis. Pooled mean prevalence rate was 8.0% (95% CI 5.0-13%). ASD questionnaire scores were higher in OCD versus control groups (standardised mean difference: 1.23; 95% CI 0.76-1.69). There was limited significant correlation between ASD questionnaire scores and OCD questionnaire scores, and no significant differences in these scores were demonstrated between OCD samples and samples diagnosed with comorbid OCD and ASD (mean difference -0.41; 95% CI -1.23 to 0.40). Functional impairment appeared elevated with ASD traits/diagnosis in OCD, but meta-analysis feasibility was limited.

conclusionsThis review indicates higher ASD traits and diagnosis in children and adolescents with OCD compared with the general population. Limited data and methodological constraints in trials limit generalisability, warranting further research.

Indexed as

adolescentsAutism Spectrum Disorderchildrenco-morbidityObsessive Compulsive Disorder

Identifiers

PMID41540573
PMCPMC12835692

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.