ArticleCNS & neurological disorders drug targets2026
Integrating Synthesis, Pharmacological Activity, and Molecular Modeling to Explore 1,2,4-Triazine Fused Thiazolidin-4-one Derivatives as GABA
Article in CNS & neurological disorders drug targets, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEpilepsy is a common neurological disorder managed with anti-epileptic drugs (AEDs), which often cause side effects and limited efficacy. This study aims to evaluate a novel series of 1,2,4-triazine fused thiazolidin-4-one derivatives for their anticonvulsant and antioxidant potential as safer and more effective therapeutic options.
methodsTwelve 1,2,4-triazine fused thiazolidin-4-one derivatives (HRSP1-HRSP12) were synthesized. Anticonvulsant activity was assessed using the maximal electroshock (MES) model, while antioxidant potential was evaluated through DPPH and FRAP assays. Cortical GABA and glutamate levels were quantified in mice. Safety was evaluated via acute toxicity studies. In silico studies included molecular docking, induced fit docking, MM-GBSA, and molecular dynamics simulations to assess GABA
resultsHRSP8 showed the strongest anticonvulsant activity among the synthesized compounds, reducing hind limb tonic extension (HLTE) to 7.91 ± 0.25 s (30 mg/kg) and 6.89 ± 0.09 s (100 mg/kg), comparable to standard drugs (phenytoin and carbamazepine). It exhibited an ED DISCUSSION: HRSP8's effects appear to involve GABAA receptor modulation and neurochemical balance restoration, with additional antioxidant support. Its safety margin and stable receptor binding indicate therapeutic promise. These results align with existing GABAergic strategies in epilepsy. Further validation in chronic models and pharmacokinetic studies is needed.
conclusionHRSP8 demonstrated notable anticonvulsant and antioxidant activities, a wide safety margin, and strong affinity for the GABA
Indexed as
Identifiers
41540531What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.