ArticleScandinavian journal of trauma, resuscitation and emergency medicine2026
External validation of the REDUCTION clinical decision aids for ruling out fractures in patients with midfacial and mandibular injuries in the emergency department: a protocol for a prospective multi-centre cohort study.
Article in Scandinavian journal of trauma, resuscitation and emergency medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundComputed Tomography (CT) is the gold standard for diagnosing midfacial and mandibular fractures in emergency department (ED) patients. However, its increasing availability has led to more frequent use, resulting in higher healthcare costs and unnecessary radiation exposure. Although various clinical parameters can assist in diagnosis of maxillofacial fractures, none are reliable enough to rule them out individually. To support clinical decision-making, and to reduce unnecessary imaging, the REDUCTION studies developed four decision aids based on combinations of clinical parameters. The aim is to rule out: (I) midfacial fractures, (II) midfacial fractures requiring active treatment, (III) mandibular fractures, and (IV) mandibular fractures requiring active treatment. Before being implemented, these aids must undergo external validation.
methodsA prospective multi-centre validation study will be conducted in six hospitals in the Netherlands. Patients presenting at the ED with midfacial and/or mandibular injury will undergo a standardized physical examination based on the parameters included in the decision aids. The X-ray images will be reviewed to assess for fractures, and electronic patient records will be analyzed to determine whether fracture treatment was active or conservative. The diagnostic accuracy of each decision aid will be determined by calculating their sensitivity, specificity, and negative predictive value. DISCUSSION: The REDUCTION validation trial will assess whether the developed clinical decision aids can be used safely to reduce unnecessary CT scans in patients with midfacial or mandibular injuries at the ED. If accurate, these decision aids could be integrated into emergency care to support decision-making, leading to fewer CT scans, lower radiation exposure, reduced healthcare costs, and safe, efficient management of maxillofacial injury.
trial registrationICTRP: NL-OMON56277.
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