Evidence map›Paper›PMID 41540386›Full record

ArticleBMC musculoskeletal disorders2026

Prospective study assessing the validity of accelerated 2D Fast Spin Echo (2D FSE) based high-resolution knee MRI and T2 mapping using deep learning reconstruction.

Xiaxia Wu, Weiyin Vivian Liu, Kejun Wang, Jiawei Jiang, Changsheng Liu, Yunfei Zha

Abstract readValidation Study
In one paragraph

Article in BMC musculoskeletal disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Xiaxia Wu *Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Weiyin Vivian Liu *MR Research, GE Healthcare, Beijing, 100176, China.
Kejun WangDepartment of Radiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Jiawei JiangSchool of Computer Science, Wuhan University, Wuhan , China.
Changsheng LiuDepartment of Radiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Yunfei ZhaDepartment of Radiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. zhayunfei999@126.com.

Funding

Interdisciplinary Innovative Talents Foundation from Renmin Hospital of Wuhan University JCRCZN-2022-013National Natural Science Foundation of China 82171895
6 · The paper itself

Abstract

backgroundA routine fast spin-echo (FSE) MRI protocol is widely used to evaluate structural injuries of the knee. While adding a T2 mapping sequence to this protocol increases sensitivity for detecting early cartilage lesions, it is time-consuming. Deep learning reconstruction (DLR) can provide accelerated, high-quality imaging but requires further clinical validation. This study aimed to evaluate the image quality and diagnostic performance of an accelerated, high-resolution 2D FSE protocol using DLR. Additionally, it sought to determine whether a routine MR imaging protocol combining an accelerated T2 mapping sequence with DLR could improve diagnostic performance for the detection of cartilage lesions, using arthroscopy as the reference standard.

methodsA total of 92 patients underwent 2D FSE based routine knee imaging on 3.0T MRI, 39 of whom also underwent sagittal T2 mapping with different k-space-based acceleration factor of 2 or 3 and then reconstructed using conventional and deep learning reconstruction algorithms as FSE

resultsInter-reader agreement of subjective assessment ranged from 0.70 (95% CI: 0.46-0.94,) to 0.89 (95% CI: 0.79-0.99,) and higher score on FSE

conclusionOur preliminary results indicate that the accelerated DLR FSE protocol provided diagnostic performance equivalent to the standard protocol for internal derangement, with potential improvement for the detection of cartilage lesions, while delivering higher image quality and quantitative T2 data within a clinically feasible scan time. These findings suggest its potential value for a comprehensive and efficient assessment of knee injury.

Indexed as

Cartilage, ArticularDeep LearningImage Interpretation, Computer-AssistedKnee InjuriesKnee JointMagnetic Resonance ImagingAdultArthroscopyFemaleHumansMaleMiddle AgedProspective StudiesReproducibility of ResultsYoung AdultArthroscopyCartilage lesionsDeep learning reconstruction (DLR)High-resolutionKneeT2 mapping

Identifiers

PMID41540386
PMCPMC12892454

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.