Evidence map›Paper›PMID 41540383›Full record

ArticleBMC pulmonary medicine2026

Matrix metalloproteinases levels in induced sputum in IPF and CTD-ILD.

Fuyun Zhang, Wei Wang, Hengyun Li, Jingqi Cao, Yi Gao, Chaofei Guo, Hongxia Hu, Yingwei Zhu, Yimin Mao, Tongsheng Wang and 1 more

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Article in BMC pulmonary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Fuyun ZhangDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, Henan, China.
Wei WangDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, Henan, China.
Hengyun LiDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, Henan, China.
Jingqi CaoDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, Henan, China.
Yi GaoDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, Henan, China.
Chaofei GuoDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, Henan, China.
Hongxia HuDepartment of Clinical Laboratory, The First Affiliated Hospital, College of Clinical Medicine of Henan of University of Science and Technology, Luoyang, Henan, China.
Yingwei ZhuDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, Henan, China.
Yimin MaoDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, Henan, China.
Tongsheng WangDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, Henan, China. wtsh730202@126.com.
Pengfei GaoDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, Henan, China. gpf_working@163.com.

Funding

Henan Provincial Medical Science and Technology Research Project LHGJ20220671Henan Provincial Science and Technology Research Project 222102310533Natural Science Foundation of Henan Province 232300421304Young Elite Scientists Sponsorship Program by Luoyang Association for Science and Technology 2022HLTJ18
6 · The paper itself

Abstract

backgroundThe involvement of matrix metalloproteinases (MMPs) in the pathogenesis of interstitial lung disease (ILD) is well-supported, and circulating MMP-7 has been validated as a biomarker. Nonetheless, there is a lack of understanding regarding the local MMPs.

methodsThe consecutive cohort comprised 30 patients with idiopathic pulmonary fibrosis (IPF), 54 with connective tissue disease (CTD)-ILD, and 34 healthy subjects. Biomarker analysis of MMP-7, MMP-8, MMP-9, and pro-MMP-10 was conducted on both plasma and induced sputum (IS) samples. The correlation between IS MMP levels, pulmonary function, and sputum cell count in ILD patients was investigated.

resultsSignificantly greater concentrations of MMPs were found in individuals with ILD compared to healthy participants. These markers were more abundant in induced sputum than plasma, with both IPF and CTD-ILD patients showing a higher median elevation in IS levels than those in the control group. The detection rate pro-MMP-10 in IS was significantly higher than in plasma (80.47% vs. 6.25%). In CTD-ILD patients, IS MMP-7 positively correlated with RV/TLC, total cell counts, and neutrophils%. IS MMP-9 showed positive correlations with total cell counts and neutrophils%. In IPF patients, IS MMP-7 levels correlated with RV/TLC, while IS MMP-9 levels correlated with FVC% pred, TLC%, and total cell counts.

conclusionsA notable increase of MMPs was observed in IS relative to plasma, correlated with inflammatory cells, lung function, and imaging features, implying that local MMPs evaluation could provide a more sensitive reflection of the pathophysiological changes in ILD.

Indexed as

Connective Tissue DiseasesIdiopathic Pulmonary FibrosisLung Diseases, InterstitialMatrix MetalloproteinasesSputumAgedBiomarkersCase-Control StudiesFemaleHumansMaleMatrix Metalloproteinase 10Matrix Metalloproteinase 7Matrix Metalloproteinase 8Matrix Metalloproteinase 9Middle AgedBiomarkersMatrix Metalloproteinase 10Matrix Metalloproteinase 7Matrix Metalloproteinase 8Matrix Metalloproteinase 9Matrix MetalloproteinasesConnective tissue diseaseIdiopathic pulmonary fibrosisInduced sputumInterstitial lung diseaseMatrix metalloproteinase

Identifiers

PMID41540383
PMCPMC12892559

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.