Evidence map›Paper›PMID 41540347›Full record

ArticleBMC microbiology2026

Impact of TNF-α (- 308G>A and - 857 C>T) promoter variants on susceptibility to chronic hepatitis B virus infection in a cohort of Mauritanian patients: pilot study.

Saffiya Mounira Ennahoui, Abdallah Sid M'Hamed, Fatimetou Veten, Sidi M Cheikh Bouna, Abdelhamid Barakat, Tetou Soumbara, Ahmed Houmeida

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Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Saffiya Mounira EnnahouiResearch Unit on Biomarkers in the Mauritanian Population, Faculty of Sciences and Technology, University of Nouakchott, Nouakchott, Mauritania.
Abdallah Sid M'HamedResearch Unit on Biomarkers in the Mauritanian Population, Faculty of Sciences and Technology, University of Nouakchott, Nouakchott, Mauritania.
Fatimetou VetenResearch Unit on Biomarkers in the Mauritanian Population, Faculty of Sciences and Technology, University of Nouakchott, Nouakchott, Mauritania.
Sidi M Cheikh Bounal'Institut National d'Hépato-Virologie (INHV), Nouakchott, Mauritania.
Abdelhamid BarakatResearch Department, Institut Pasteur du Maroc, Casablanca, Morocco.
Tetou SoumbaraResearch Unit on Biomarkers in the Mauritanian Population, Faculty of Sciences and Technology, University of Nouakchott, Nouakchott, Mauritania. tetousoumbara09@gmail.com.ORCID 0009-0007-1797-824X
Ahmed HoumeidaResearch Unit on Biomarkers in the Mauritanian Population, Faculty of Sciences and Technology, University of Nouakchott, Nouakchott, Mauritania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenetic polymorphisms within the tumor necrosis factor (TNF) cluster have been implicated in several diseases. This exploratory study aimed to assess the role of two polymorphisms (− 308G > A and − 857 C > T) in the TNF-α gene in the risk of developing chronic Hepatitis B virus (CHB) infection in a cohort of Mauritanian patients.

methodsWe selected 160 subjects, including 82 patients with CHB and 78 spontaneously cured controls. Following PCR amplification, the targeted DNA regions were sequenced using the Sanger method.

resultsThe TNF-α-308 G > A (rs1800629) wild-type GG genotype was significantly associated with decreased susceptibility to CHB (OR = 0.13 (0.045–0.379), p < 0.001). In contrast, the A mutant allele was identified as a risk factor for HBV persistence (OR = 0.310 (0.132–0.728), p = 0.007). The TNF-α-857 C > T (rs1799724) polymorphism was not associated with CHB, although the minor allele T was linked with a high viral load (OR = 0.14(0.03–0.76), p = 0.022).

conclusionOur results suggest a possible association between TNF-α-308 G > A (rs1800629) variation and the evolution of HBV infection to a chronic state in Mauritanian patients.

Indexed as

Genetic Predisposition to DiseaseHepatitis B, ChronicPolymorphism, Single NucleotidePromoter Regions, GeneticTumor Necrosis Factor-alphaAdultCohort StudiesFemaleGene FrequencyGenotypeHepatitis B virusHumansMaleMauritaniaMiddle AgedPilot ProjectsTumor Necrosis Factor-alphaChronic infectionHepatitis B virusMauritaniaPolymorphismTNF-α

Identifiers

PMID41540347
PMCPMC12947466

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.