ArticleBMC microbiology2026
Antibacterial activity and mechanism analysis of deoxycholic acid against Clostridium perfringens.
Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Antibacterial effects of silver and titanium dioxide nanoparticles-coated orthodontic arch wires: in vitro study.BMC oral health · 2026Article
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Authors and funding
7 authors.
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Abstract
backgroundDeoxycholic acid (DCA), a gut microbiota-derived secondary metabolite, exhibits broad-spectrum antimicrobial activity, particularly against Clostridium perfringens(C. perfringens). However, its specific antibacterial mechanism remains unclear.
objectiveTo investigate the antibacterial activity and mechanism of DCA against C. perfringens, this study employed in vitro experiments combined with transcriptomic analysis to explore the inhibitory effects and underlying mechanism of DCA on C. perfringens.
resultThe results indicate that DCA can effectively inhibit the formation of C. perfringens biofilms, disrupt their cell walls, increase cell membrane permeability, and cause nucleic acid leakage. Transcriptome analysis revealed that DCA can up-regulating the oxidative phosphorylation pathway in C. perfringens and down-regulating antioxidant activity, peroxidase activity, and oxidoreductase activity, suggesting its potential antibacterial mechanism. This study provides insights into the antimicrobial activity of DCA and its mechanisms, laying a theoretical foundation for its development as a novel antimicrobial agent or feed additive.
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