Evidence map›Paper›PMID 41540320›Full record

ArticleDrug delivery and translational research2026

A novel murine model of LITT for glioblastoma reveals tumor reduction, BBB permeabilization, and drug delivery via ThermoDox

Prazwal Athukuri, Karina Moreno, Malcolm F McDonald, Ashley Puentes, Alfred Dei-Ampeh, Anantha Marisetty, Yuhui Yang, Sungho Lee, Khatri Latha, David Needham and 1 more

Abstract read
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In one paragraph

Article in Drug delivery and translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Prazwal AthukuriDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Karina MorenoDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Malcolm F McDonaldDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Ashley PuentesDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Alfred Dei-AmpehDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Anantha MarisettyDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Yuhui YangDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Sungho LeeDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Khatri LathaDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
David NeedhamDepartment of Mechanical Engineering and Materials Science, School of Engineering, Duke University, Durham, NC, 27708-0300, USA.
Ganesh RaoDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA. grao@bcm.edu.ORCID http://orcid.org/0000-0003-3609-3491

Funding

Laser Interstitial Thermal Therapy for the Treatment of GlioblastomaR21NS123589 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI RAO, GANESH · 2021 to 2021
$440k
NINDS NIH HHS R21 NS123589NINDS NIH HHS R21NS123589
6 · The paper itself

Abstract

Laser interstitial thermal therapy (LITT) is a minimally invasive treatment for brain tumors that are recurrent or surgically inaccessible. We developed a murine model of LITT to investigate its effects on tumor burden, immune activation, and delivery of heat-activated therapeutics. We engineered a preclinical LITT system using a 1064-nm laser coupled to a 400-μm fiber-optic probe. Orthotopic gliomas were established in the right frontal cortex of BL6 mice using luciferase-transduced glioma cells. Ten days post-implantation, mice were treated with LITT (0.45 or 0.75 W). Tumor response and blood-brain barrier (BBB) disruption were assessed using bioluminescence imaging (BLI), Evans Blue dye, and histology at 3, 7, and 14 days post-treatment. Immunofluorescence (IF) staining characterized immune cell activation. The distribution of doxorubicin released from intravenously administered Thermodox

Indexed as

Antibiotics, AntineoplasticBlood-Brain BarrierBrain NeoplasmsDoxorubicinGlioblastomaHyperthermia, InducedLaser TherapyAnimalsCell Line, TumorDisease Models, AnimalDrug Delivery SystemsHumansMiceMice, Inbred C57BLAntibiotics, AntineoplasticDoxorubicinBlood–brain-barrier permeabilityGlioblastomaLaser interstitial thermal therapyThermosensitive liposomes

Identifiers

PMID41540320

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.